Reproductive toxicity of acetamiprid in male Guinea pig (Cavia porcellus)

Kenfack, Augustave; Guiekep, Arthénice Jemima Nounamo; Ferdinand, Ngoula; Vemo, Bertin Narcisse; Bouli, Freddy Patrick Ngah Osoe; Pamo, E. Tedonkeng

doi:10.31248/jasvm2018.101

Cited by 13 publications

(8 citation statements)

References 20 publications

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“…Results revealed that co-administration of C. bauchiense leaves ethanolic extract with heavy metal in rabbits does restore CAT, SOD and peroxidase activities and MDA level at the reference values. Kenfack et al (2018) showed similar results in male guinea pigs receiving 80 mg/kg bw of acetamiprid for 90 days, concerning the control group. This was similar to the report made by (Vemo et al, 2017) in guinea pigs exposed to cypermethrin (137.5 mg/kg bw) only, as compared with those co-treated with ethanolic extract of B. engleriana leaves.…”

Section: Discussionsupporting

confidence: 66%

Effects of Crassocephalum bauchiense Ethanolic Extract on Reproductive Parameters in Rabbit Does Exposed to Potassium Dichromate

Momo¹,

Pascal²,

Pasima³

et al. 2021

American Journal of Animal and Veterinary Sciences

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The present study was undertaken to evaluate the effects of Hutch leaves Ethanolic Extract (EE) on reproductive parameters, toxicity biochemical markers and oxidative stress indicators in does exposed to Potassium Dichromate (PD). Thirty-six nulliparous sexually mature does of eight months; weighing 2.80-3.00 kg were divided into six groups of six animals, comparable in terms of Body Weight (BW). After mating, group T0 received distilled water, while groups T0-, VC100, EE100, EE200 and EE400 were treated with 40 mg/BW of PD. Also, group VC100 received 100 mg/BW of vitamin C, while groups EE100, EE200 and EE400 received respectively 100, 200 and 400 mg/BW of EE of hutch leaves. Results showed that urea, creatinine, total cholesterol, alanine aminotransferase and aspartate aminotransferase were significantly higher; with lower total protein levels in T0-concerning the other groups. The follicle-stimulating hormone was significantly lower in T0-as compared to the other groups. Catalase and total peroxidase activities decreased significantly while malondialdehyde and superoxide dismutase increased significantly in T0-than in other groups. From these results, EE of Hutch leaves has protected does against the toxic effects of PD. It can therefore be used to improve female reproduction.

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Section: Discussionsupporting

confidence: 66%

Effects of Crassocephalum bauchiense Ethanolic Extract on Reproductive Parameters in Rabbit Does Exposed to Potassium Dichromate

Momo¹,

Pascal²,

Pasima³

et al. 2021

American Journal of Animal and Veterinary Sciences

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“…This is in tandem with another study which also observed that rats had lower sperm counts after 45 days of acetamiprid and these rats revealed a significant decrease in sperm motility and increased rates of abnormal morphology (Mosbah et al 2018). Exposure to neonicotinoid insecticides as acetamiprid at 26.67, 40, and 80 mg/kg body weight for 90 days leads to a significant reduction in sperm motility and count of epididymal sperm and a significant increment in the rate of abnormal sperms when compared to the control group (Kenfack et al 2018). However, Quinalphos exposure at 1.0 mg/kg resulted in a significant reduction in motility and increment in sperm head defects and DNA damage (Kumari et al 2021).…”

Section: Discussionsupporting

confidence: 73%

Reproductive effects of sulfoxaflor in male Sprague Dawley rats

Mohamed

Ali

Yahia

et al. 2022

Environ Sci Pollut Res

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The study objective was to evaluate the potential reproductive toxicity of sulfoxaflor (SFX) insecticide in male Sprague Dawley rats. To attain these objectives, forty male Sprague Dawley rats of 10–12 weeks old were randomly divided into four equal groups; the 1st group was used as a control group; the other three groups were exposed to 25, 100, and 500 mg/kg body weight SFX by oral gavage for 4 weeks. Relative testicular weight, testosterone, FSH, LH, MDA, and GPx levels, sperm viability, sperm morphology, sperm DNA damage, and histopathological changes in testes, epididymis, and seminal vesical of these rats were investigated after 4 weeks. The results showed that SFX exposure resulted in a significant increase in FSH, LH, MDA, and GPx levels as well as the percentage of dead and abnormal sperms and DNA damage in rat sperms. Histopathological examination of testes established testicular degeneration with coagulative necrosis as well as the proliferation of interstitial connective tissue infiltrated with inflammatory cells with congestion of intertubular blood vessels in epididymis and degeneration of lining epithelium of seminal vesicles.

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“…Reactive oxygen species (ROS) production in the testis leads to oxidative damage and destroys steriodogenesis and spermatogenesis 28 . Some studies showed acetamiprid induced lipid peroxidation and reduced antioxidant enzymatic activity in the testes 12,18 . In the current study, acetamiprid led to lipid peroxidation, GSH depletion, increase in TOS, and decrease in TAS in testis homogenates in a dose dependent manner.…”

Section: Discussionmentioning

confidence: 99%

Reproductive effects of subchronic exposure to acetamiprid in male rats

Arıcan

Kayalı

Karaca

et al. 2020

Sci Rep

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Acetamiprid, a selective agonist of nicotinic acetylcholine recetors, is one of the most widely used neonicotinoids. There is limited data about toxicity of acetamiprid on male reproductive system. Therefore, the study aimed to investigate the reproductive toxic potential of acetamiprid in male rats orally treated with acetamiprid with low (12.5 mg/kg) medium (25 mg/kg) or high dose (35 mg/kg) for 90 days. According to our results, sperm concentration and plasma testosterone levels decreased in dose dependent manner. Gonadotropin-releasing hormone (GnRH), follicle-stimulating hormeone (FSH), luteinizing hormone (LH) levels increased at low and medium dose groups and acetamiprid caused lipid peroxidation and glutathione (GSH) depletion in the testes. Histologic examinations revealed that acetamiprid induced apoptosis in medium and high dose groups and proliferation index dramatically decreased in high dose group. In conclusion, acetamiprid caused toxicity on male reproductive system in the high dose. The mechanism of the toxic effect may be associated with oxidative stress, hormonal disruptions and apoptosis. Neonicotinoids are new class of insecticides that act as selective nicotinic acetylcholine receptor (nAChR) agonist selectively in central nervous system of insects 1. Acetamiprid, one of the neonicotinoid insecticides, is commonly used for agricultural and domestic purposes against a large variety of insects 2,3. Acetamiprid has been reported to accumulate in plants and contaminate water and this can pose a potential risk for human health 4,5. Acetamiprid is absorbed easily after oral administration, and it is determined at the highest concentration in the liver, kidney, adrenal and thyroid glands 6. Some researchers showed that acetamiprid caused toxic effects on several organ systems, including the nervous, respiratory, and immune systems in the experimental models 7-9. Furthermore, it has been reported acute poisoning cases after ingestion of acetamiprid in humans 10,11. Acetamiprid has also been reported to induce reproductive toxicity in different species 12,13. The cross-sectional epidemiological study which was conducted in Kavar, (Iran) showed acetamiprid reduced the number of sperm in farmers who exposed to acetamiprid 14. As the use of acetamiprid is increasing, it is very important to identify the toxicity of acetamiprid. Additionally, acetamiprid can be used in combinations with other insecticide because of that, toxic effects and doses of acetamiprid are needed to elucidate well by chronic and subchronic toxicity studies. Acetamiprid has been shown toxic effects on many organs and systems. However, there is no satisfied information on the toxicity potential of acetamiprid on male reproductive system. In this study, it was aimed to examine the effects of acetamiprid on reproductive function of male rats in terms of oxidative stress, apoptosis, hormonal disruptions and histopathological changes. Results Effect of acetamiprid on body and testicular weights. Liver steatosis and slowness of the movem...

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Reproductive toxicity of acetamiprid in male Guinea pig (Cavia porcellus)

Cited by 13 publications

References 20 publications

Effects of Crassocephalum bauchiense Ethanolic Extract on Reproductive Parameters in Rabbit Does Exposed to Potassium Dichromate

Effects of Crassocephalum bauchiense Ethanolic Extract on Reproductive Parameters in Rabbit Does Exposed to Potassium Dichromate

Reproductive effects of sulfoxaflor in male Sprague Dawley rats

Reproductive effects of subchronic exposure to acetamiprid in male rats

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