Reproductive toxicity of chlorpyrifos tested in zebrafish (<i>Danio rerio</i>)

Manjunatha, Bangeppagari; Philip, Gundala Harold

doi:10.1177/0748233715589445

Cited by 36 publications

(23 citation statements)

References 49 publications

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“…The histopathological alterations observed in our study were dose-and duration-dependent because after 15 and 45 days of exposure to 150 µg/L, cytoplasmic degenerations like CC and CR were observed, indicating the negative feedback of estrogens to hypothalamic-pituitary-gonadal axis of this fish (Tillitt et al, 2010). Earlier studies demonstrated a strong negative correlation between the damaged ovarian structures and levels of estrogen production in fish exposed to different pesticides (Maxwell and Dutta, 2005;Manjunatha and Philip, 2016). Deka and Mahanta (2012) observed cytoplasmic degenerations in Stinging Catfish (Heteropneustes fossilis) ovary when exposed to 200 µg/L malathion for 10 days.…”

Section: Effects Of Chlorpyrifos On Ovarymentioning

confidence: 85%

“…The aquatic contamination by pesticides used in agriculture may constitute potential (eco)toxicological risks to non-target aquatic organisms of different trophic levels in a food chain i.e. primary producers (Daam et al, 2008a;Malev et al, 2012;Liu et al, 2013;Kumar et al, 2014), invertebrates (Maltby et al, 2005;Palma et al, 2009;Rubach et al, 2011;Roessink et al, 2013;Van den Brink et al, 2016), and fish (Tillitt et al, 2010;Marimuthu et al, 2013;Manjunatha and Philip, 2016;, when exceeding the threshold levels.…”

Section: Potential Effects Of Pesticides On the Aquatic Environmentmentioning

confidence: 99%

“…The release of this insecticide into the aquatic environment may have potential toxic effects on non-target aquatic organisms like invertebrates (Maltby et al, 2005;Daam et al, 2008;Palma et al, 2008;Rubach et al, 2011;, and vertebrates (Maltby et al, 2005;Oruç, 2010;Bernabò et al, 2011;Manjunatha and Philip, 2016;. Among vertebrates, fish is often used as suitable bio-indicator, because of their wide distribution in aquatic environment, long lifespan, free swimming, ability to respond against environmental xenobiotics, and importance as a food source for human beings (Gupta et al, 2009;Narra et al, 2011;Correia et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Chlorpyrifos is reported to affect growth (Huynh and Nugegoda, 2012), survival (Oruç, 2010;Mhadhbi and Beiras, 2012), haematological profiles (Nwani et al, 2013;Narra et al, 2015), hepatic dysfunction (Oruç, 2012), neuro-behavioral dysfunction (Levin et al, 2004), oxidative stress (Oruç, 2012), genotoxic stress , cytotoxic stress (Palanikumar et al, 2014) and reproduction (De Silva and Samayawardhena, 2005;Hou et al, 2009;Oruç, 2010;Juberg et al, 2013;Lauan and Ocampo, 2013;Manjunatha and Philip, 2016;Brandt et al, 2015) in different fish species, but not yet on Banded Gourami (Trichogaster fasciata) for any of the endpoints as per our literature survey.…”

Section: Introductionmentioning

confidence: 99%

“…2921-88-2; O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate) is a broad spectrum organophosphate synthetic insecticide and acaricide (Yen et al, 2011;Manjunatha and Philip, 2016). Chlorpyrofis was introduced for agricultural and household applications in the USA in 1965 (Juberg et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Effects of insecticides on aquatic ecosystems in Bangladesh

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Section: Effects Of Chlorpyrifos On Ovarymentioning

confidence: 85%

Section: Potential Effects Of Pesticides On the Aquatic Environmentmentioning

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

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Section: Introductionmentioning

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Recent Advances in Silver nanozymes: Concept, Mechanism, and Applications in Detection

Mishra

Abdal‐hay

Rather

et al. 2022

Adv Materials Inter

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physicochemical properties that are entirely different from those of their bulk counterparts. They have been exploited vigorously for numerous applications, including in medical and nonmedical fields. However, one must not realize it to be a novel technology, as its roots can be traced centuries ago. For instance, copper and silver (Ag) NPs can be dated back to the 9 th century, when they were used to shine the ceramic artifacts. [1] One of the earlier and renowned examples is the Lycurgus cup, made by the Romans in the 4 th century using Au-Ag alloy NPs to produce greenish-red color. [2] Even though the use of NPs could be found in many such old works of literature; their real potential was not completely understood until 1959, when Richard Feynman delivered the renowned lecture "There's Plenty of Room at the Bottom: An Invitation to Enter a New Field of Physics. [3] This brought in a stream of exceptional studies, and researchers were able to assign quantum size effects as the reason for a change of properties when moving from bulk to nano regime. As things became more and more precise, nanomaterials began to find their extensive role in varied applications. One of the significant applications was their role as enzyme mimetics due to their excellent catalytic properties.The metabolic reactions in our body are catalyzed by the protein molecules called enzymes. It was James B Sumner who, in 1926, established the first enzyme, urease, to be a protein, which won him a Nobel Prize for this discovery in 1946. [4] All the enzymes have been considered protein molecules ever since. However, due to their high production cost and rapid denaturation under variable pH and temperature settings, they have limited their industrial applications. [5] Therefore, a need was felt to develop enzyme mimicking materials, more precisely termed "artificial enzymes" by Robert Breslow. [6] These catalytically active molecules can be anything from polymers, cyclodextrins to supramolecules and dendrimers, showing enzyme-like activity. [7][8][9][10] Recently, the discovery of dismutaselike activity of fullerene derivatives [11,12] and peroxidase-mimicking catalysis of Fe 3 O 4 NPs [13,14] enunciated the promising career of NPs in the field of biomimetics. The importance and broad prospect of nanozymes can be understood in Figure 1. This shows the increasing number of publications each year on nanozymes. These nanozymes have been majorly used Natural enzymes accelerate substrate-specific reactions making them of exquisite interest for various applications. However, their appeal is lost in a practical setting due to low stability and high preparation expenses. This is the primary reason behind the flourishing in the research of nanozyme, i.e., artificial enzymes, in the past decade. Their unique physicochemical properties make them a promising candidate for various applications, especially in diagnostics and detection. They possess an enzyme-like activity and can overcome the drawbacks of natural protein-based enzymes. Nanozymes are nanomateri...

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Estrogenic regulation of claudin 5 and tight junction protein 1 gene expression in zebrafish: A role on blood–brain barrier?

Pellegrini,

Fernezelian,

Malleret

et al. 2023

J of Comparative Neurology

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The blood–brain barrier (BBB) is a physical interface between the blood and the brain parenchyma, playing key roles in brain homeostasis. In mammals, the BBB is established thanks to tight junctions between cerebral endothelial cells, involving claudin, occludin, and zonula occludens proteins. Estrogens have been documented to modulate BBB permeability. Interestingly, in the brain of zebrafish, the estrogen‐synthesizing activity is strong due to the high expression of Aromatase B protein, encoded by the cyp19a1b gene, in radial glial cells (neural stem cells). Given the roles of estrogens in BBB function, we investigated their impact on the expression of genes involved in BBB tight junctions. We treated zebrafish embryos and adult males with 17β‐estradiol and observed an increased cerebral expression of tight junction and claudin 5 genes in adult males only. In females, treatment with the nuclear estrogen receptor antagonist (ICI182,780) had no impact. Interestingly, telencephalic injuries performed in males decreased tight junction gene expression that was partially reversed with 17β‐estradiol. This was further confirmed by extravasation experiments of Evans blue showing that estrogenic treatment limits BBB leakage. We also highlighted the intimate links between endothelial cells and neural stem cells, suggesting that cholesterol and peripheral steroids could be taken up by endothelial cells and used as precursors for estrogen synthesis by neural stem cells. Together, our results show that zebrafish provides an alternative model to further investigate the role of steroids on the expression of genes involved in BBB integrity, both in constitutive and regenerative physiological conditions. The link we described between capillaries endothelial cells and steroidogenic neural cells encourages the use of this model in understanding the mechanisms by which peripheral steroids get into neural tissue and modulate neurogenic activity.

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Reproductive toxicity of chlorpyrifos tested in zebrafish (Danio rerio)

Cited by 36 publications

References 49 publications

Effects of insecticides on aquatic ecosystems in Bangladesh

Effects of insecticides on aquatic ecosystems in Bangladesh

Recent Advances in Silver nanozymes: Concept, Mechanism, and Applications in Detection

Estrogenic regulation of claudin 5 and tight junction protein 1 gene expression in zebrafish: A role on blood–brain barrier?

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