2021
DOI: 10.1021/acsnano.1c04363
|View full text |Cite
|
Sign up to set email alerts
|

Reprogramming of Neutrophils as Non-canonical Antigen Presenting Cells by Radiotherapy–Radiodynamic Therapy to Facilitate Immune-Mediated Tumor Regression

Abstract: Ineffective antigen cross-presentation in the tumor microenvironment compromises the generation of antitumor immune responses. Radiotherapy–radiodynamic therapy (RT-RDT) with nanoscale metal–organic frameworks (nMOFs) induces robust adaptive immune responses despite modest activation of canonical antigen presenting dendritic cells. Here, using transplantable and autochthonous murine tumor models, we demonstrate that RT-RDT induces antitumor immune responses via early neutrophil infiltration and reprogramming. … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
27
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
8

Relationship

3
5

Authors

Journals

citations
Cited by 29 publications
(27 citation statements)
references
References 58 publications
0
27
0
Order By: Relevance
“…Gr‐1 + F4/80 med myeloid cells including granulocytes and myeloid‐derived suppressor cells (MDSCs) accumulated in MOL(+) and cGAMP/MOL(+) treated tumors (Figure 4f), which is consistent with previous observations on nanoscale metal–organic frameworks (MOFs) and other nanoparticles. [ 39 ] cGAMP/MOL(+) caused infiltration of F4/80 high macrophages and CD11c + MHCII + DCs in tumors, where no obvious polarization of macrophages was found between pro‐inflammatory M1 (F4/80 high CD86 + ) macrophages and anti‐inflammatory M2 (F4/80 high CD206 + ) macrophages. In lymph nodes, however, the treatment induced an obvious polarization of macrophages to anti‐inflammatory M2 state with a lower M1/M2 ratio, and together with a higher percentage of CD8 + DCs for the possible cross‐priming process (Figure 4g–i and Figure S17, Supporting Information).…”
Section: Resultsmentioning
confidence: 99%
“…Gr‐1 + F4/80 med myeloid cells including granulocytes and myeloid‐derived suppressor cells (MDSCs) accumulated in MOL(+) and cGAMP/MOL(+) treated tumors (Figure 4f), which is consistent with previous observations on nanoscale metal–organic frameworks (MOFs) and other nanoparticles. [ 39 ] cGAMP/MOL(+) caused infiltration of F4/80 high macrophages and CD11c + MHCII + DCs in tumors, where no obvious polarization of macrophages was found between pro‐inflammatory M1 (F4/80 high CD86 + ) macrophages and anti‐inflammatory M2 (F4/80 high CD206 + ) macrophages. In lymph nodes, however, the treatment induced an obvious polarization of macrophages to anti‐inflammatory M2 state with a lower M1/M2 ratio, and together with a higher percentage of CD8 + DCs for the possible cross‐priming process (Figure 4g–i and Figure S17, Supporting Information).…”
Section: Resultsmentioning
confidence: 99%
“…Th-DBP showed 1.61-fold and 1.48-fold higher surface calreticulin (CRT) expressions than Hf-DBP under X-ray and γ-ray irradiation, respectively (Figures 3d and S10). [27,[45][46][47] Owing to the enhanced RT-RDT effect, Th-DBP gave 1.51-fold and 1.56-fold apoptotic cell death over Hf-DBP under X-ray (Figure 3e) and γ-ray (Figures 3f and S11) irradiation, respectively.…”
Section: Methodsmentioning
confidence: 99%
“…In vitro 2′,7′‐dichlorodihydrofluorescein diacetate (DCF‐DA) assays showed that Th‐DBP exhibited 1.16‐fold and 1.08‐fold higher ROS signals than Hf‐DBP under X‐ray and γ‐ray irradiation, respectively (Figures 3c and S10). Th‐DBP showed 1.61‐fold and 1.48‐fold higher surface calreticulin (CRT) expressions than Hf‐DBP under X‐ray and γ‐ray irradiation, respectively (Figures 3d and S10) [27, 45–47] . Owing to the enhanced RT‐RDT effect, Th‐DBP gave 1.51‐fold and 1.56‐fold apoptotic cell death over Hf‐DBP under X‐ray (Figure 3e) and γ‐ray (Figures 3f and S11) irradiation, respectively.…”
Section: Figurementioning
confidence: 99%
“…793,794 Hafnium-based materials with strong X-ray absorption are used as radiosensitizers to enhance the radiotherapeutic efficacy of tumors. [795][796][797] Gold nanorods, copper sulfide, and MXenes can effectively convert light into heat energy when irradiated by near-infrared light, thus achieving tumor ablation through photothermal therapy (PTT). [651][652][653]798 Fe 3 O 4 nanoparticles effectively decompose H 2 O 2 into highly toxic OH in the tumor microenvironment and cause tumor cell death via apoptosis and ferroptosis; this method is known as chemodynamic therapy (CDT).…”
Section: Biomedicinementioning
confidence: 99%