2019
DOI: 10.1016/j.ijantimicag.2019.03.024
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Repurposing disulfiram for treatment of Staphylococcus aureus infections

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Cited by 39 publications
(27 citation statements)
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“…Most demonstrations of an antibacterial effect of DSF were performed in vitro (24,25), at concentrations not always compatible with its in vivo use. For instance, one study claims that DSF is toxic to Mycobacterium tuberculosis, including the dormant form, both in vitro and in vivo (24).…”
Section: Other Modes Of Action Of Dsfmentioning
confidence: 99%
“…Most demonstrations of an antibacterial effect of DSF were performed in vitro (24,25), at concentrations not always compatible with its in vivo use. For instance, one study claims that DSF is toxic to Mycobacterium tuberculosis, including the dormant form, both in vitro and in vivo (24).…”
Section: Other Modes Of Action Of Dsfmentioning
confidence: 99%
“…2018 disulfiram, an antialcoholic drug used as antibacterial [40,75] ; and Diphenyleneiodonium chloride, an nitric oxide synthase inhibitor used as antibacterial. [76] However, drug repurposing is also defined as the strategy of finding a new use of existing drugs, and it is also called drug repositioning or redirecting.…”
Section: Of 15mentioning
confidence: 99%
“…The development of new antimicrobials is a very slow process and is frequently beset with a large number of obstacles [ 10 , 11 ]. Repurposing approved drugs is a promising alternative strategy, and these drugs have the ability to go directly to preclinical and clinical trials, reducing cost and time [ 12 ].…”
Section: Introductionmentioning
confidence: 99%