Repurposing of genistein as anti-sickling agent: elucidation by multi spectroscopic, thermophoresis, and molecular modeling techniques

Syed, Muntjeeb M.; Doshi, Pooja; Bharshankh, Ankita; Dhavale, Dilip D.; Kate, Sudam L.; Kulkarni, Girish; Doshi, Jignesh; Kulkarni, Mukund G.

doi:10.1080/07391102.2020.1852967

Cited by 4 publications

(2 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…44 The CD results are expressed in terms of the mean residue ellipticity (MRE) and the a helical content was calculated using the CDNN program version 2.1.0.223. 45,46 The data indicate that in the presence of XD-4 the a-helix conformation of HSA was found to be decreased from 69% to 55%. By contrast, with the addition of XD-6 the a-helix conformation of HSA decreased from 69% to 53%.…”

Section: Adhesion Inhibition Activitymentioning

confidence: 95%

Synthesis and antifungal screening of tetramethyl hexahydro-1H-xanthene-1,8(2H)-dione derivatives as potential inhibitors of morphogenesis and biofilm formation inCandida albicans

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Adhesion Inhibition Activitymentioning

confidence: 95%

Synthesis and antifungal screening of tetramethyl hexahydro-1H-xanthene-1,8(2H)-dione derivatives as potential inhibitors of morphogenesis and biofilm formation inCandida albicans

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In a recent study Vallejos-Sánchez et al [21] used MST, NMR and ITC to confirm no binding between pyrazinoic and ribosomal protein S1. Molecular dynamics and docking simulations are also used as complementary to identify the structural features that control affinities of binding [59,60]. Usually good correlations are obtained between the computed K D value and the MST-derived k D values [61,62].…”

Section: Estimation Of Binding Parametersmentioning

confidence: 99%

Microscale thermophoresis as a powerful growing analytical technique for the investigation of biomolecular interaction and the determination of binding parameters

Deeb

Al‐Harrasi

Khan

et al. 2022

Methods Appl. Fluoresc.

View full text Add to dashboard Cite

The in vitro panel of technologies to address biomolecular interactions are in play, however microscale thermophoresis is continuously increasing in use to represent a key player in this arena. This review highlights the usefulness of microscale thermophoresis in the determination of molecular and biomolecular affinity interactions. This work reviews the literature from January 2016 to January 2022 about microscale thermophoresis. It gives a summarized overview about both the state-of the art and the development in the field of microscale thermophoresis. The principle of microscale thermophoresis is also described supported with self-created illustrations. Moreover, some recent advances are mentioned that showing application of the technique in investigating biomolecular interactions in different fields. Finally, advantages as well as drawbacks of the technique in comparison with other competing techniques are summarized.

show abstract

Isoflavones and Noncommunicable Diseases: Pharmacological Perspectives

Yeram,

Vora,

Kulkarni

2023

Reference Series in Phytochemistry

View full text Add to dashboard Cite

Repurposing of genistein as anti-sickling agent: elucidation by multi spectroscopic, thermophoresis, and molecular modeling techniques

Cited by 4 publications

References 55 publications

Synthesis and antifungal screening of tetramethyl hexahydro-1H-xanthene-1,8(2H)-dione derivatives as potential inhibitors of morphogenesis and biofilm formation inCandida albicans

Synthesis and antifungal screening of tetramethyl hexahydro-1H-xanthene-1,8(2H)-dione derivatives as potential inhibitors of morphogenesis and biofilm formation inCandida albicans

Microscale thermophoresis as a powerful growing analytical technique for the investigation of biomolecular interaction and the determination of binding parameters

Isoflavones and Noncommunicable Diseases: Pharmacological Perspectives

Contact Info

Product

Resources

About