Requirement of inner cell mass for efficient chorionic gonadotrophin secretion by blastocysts of common marmosets (Callithrix jacchus)

Summers, P.M.; Taylor, Cormac T.; Miller, Mill W.

doi:10.1530/jrf.0.0970321

Reproduction

1993

DOI: 10.1530/jrf.0.0970321

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Requirement of inner cell mass for efficient chorionic gonadotrophin secretion by blastocysts of common marmosets (Callithrix jacchus)

P.M. Summers¹,

Cormac T. Taylor²,

Mill W. Miller³

Abstract: The role of the inner cell mass in the induction of chorionic gonadotrophin synthesis and secretion by the trophoblast of the peri-implantation primate blastocyst was studied in common marmoset monkeys.

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Cited by 10 publications

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“…A deficiency in inner cell mass viability can influence CG production, and ICM deficiencies have been shown previously in in uitro fertilized rhesus embryos [l I]. It has been demonstrated in marmoset embryos that the inner cell mass contributes undefined factors, which can promote CG secretion in uitro [29]. The progesterone supplementation given to recipient females could have contributed to the attenuation of mCG.…”

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confidence: 86%

Pregnancy and live birth from nonsurgical transfer of in vivo‐ and in vitro ‐produced blastocysts in the rhesus monkey

Wolfgang

Eisele

Knowles

et al. 2001

J of Medical Primatology

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Embryo transfer in the rhesus monkey has been historically limited to transfer of cleavage stage embryos. In order to allow genetic manipulation of rhesus embryos in vitro, without using invasive surgical techniques, it is important to explore the transfer of morula and blastocyst stage embryos. Embryos were produced by in vitro fertilization from gonadotropin-stimulated monkeys, or were obtained by nonsurgical uterine flushing of naturally mated or artificially inseminated females. Nonsurgical transfer was accomplished by inserting a metal guide through the cervix into the uterus, after which a hollow cell sampler was inserted over the guide. The guide was removed and a catheter was inserted containing one to five embryos. Several pregnancies resulted from in vitro- and in vivo-derived blastocysts, and two pregnancies were carried to term resulting in one live birth. Blood samples were collected regularly to monitor plasma levels of chorionic gonadotropin, luteinizing hormone, and progesterone. The recipients received progesterone as a subcutaneous implant or daily injections from the day of transfer. The approach described in this study provides the opportunity to explore transgenic and chimeric models in the monkey by the development of noninvasive methods to transfer late-stage embryos that have been manipulated in vitro.

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confidence: 86%

Pregnancy and live birth from nonsurgical transfer of in vivo‐ and in vitro ‐produced blastocysts in the rhesus monkey

Wolfgang

Eisele

Knowles

et al. 2001

J of Medical Primatology

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Detection of pregnancy and monitoring patterns of uterine and fetal growth in the marmoset monkey (Callithrix jacchus) by real‐time ultrasonography

Oerke

Einspanier

Hodges

1995

American J Primatol

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The purpose of this study was to evaluate the potential of real-time ultrasonography for detecting and monitoring pregnancy in the common marmoset, Ultrasound was performed transabdominally on unsedated females using a 7.5 MHz linear or intraoperative sector probe. Pregnancies were timed using progesterone measurements in twice weekly blood samples to determine the day of ovulation. Eight pregnancies were examined three times a week until day 30, twice a week until day 80, and once a week until birth. Detection of pregnancy was possible on day 15, on average, by the appearance of a double endometrial echo indicating fluid accumulation in the uterus. The uterine lumen thus formed was first measurable on day 21 on average. Diameter of the pregnant uterus was significantly greater than that of the nonpregnant organ by day 38. Thereafter, the dimensions of uterus and uterine lumen showed a similar pattern of growth until day 75, when measurements became inaccurate due to increasing uterine pliability. Embryonic development was characterized by the initial expansion of the gestation sacs and the appearance of individual embryos by day 33. Detection of heart beat at approximately day 54 allowed confirmation of number and viability of the embryos. With the visualization of the skulls by day 82, it was possible to determine fetal position and to monitor fetal growth by measurement of the biparietal diameter. All pregnancies were of normal length (140-145 days) resulting in viable offspring. It can be concluded that ultrasonography is suitable for detecting and monitoring pregnancy in the marmoset monkey and as a non-invasive method, has the potential for being routinely used in this and other species of Callitrichidae. o 1995 Wiley-Liss, Inc.

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Phylogeny, ontogeny and embryo transfer

Betteridge

1995

Theriogenology

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Requirement of inner cell mass for efficient chorionic gonadotrophin secretion by blastocysts of common marmosets (Callithrix jacchus)

Abstract: The role of the inner cell mass in the induction of chorionic gonadotrophin synthesis and secretion by the trophoblast of the peri-implantation primate blastocyst was studied in common marmoset monkeys.

Cited by 10 publications

References 16 publications

Pregnancy and live birth from nonsurgical transfer of in vivo‐ and in vitro ‐produced blastocysts in the rhesus monkey

Pregnancy and live birth from nonsurgical transfer of in vivo‐ and in vitro ‐produced blastocysts in the rhesus monkey

Detection of pregnancy and monitoring patterns of uterine and fetal growth in the marmoset monkey (Callithrix jacchus) by real‐time ultrasonography

Phylogeny, ontogeny and embryo transfer

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