2020
DOI: 10.1038/s41586-020-2563-7
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Rescue of oxytocin response and social behaviour in a mouse model of autism

Abstract: Chadman, K. K. et al. Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice.

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Cited by 112 publications
(103 citation statements)
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“…The change in social behavior was dependent on an intact vagus nerve and absent in animals lacking the oxytocin receptor in dopaminergic neurons of the ventral tegmental area (Sgritta et al 2019). Also, restoration of oxytocin-signaling in the dopaminergic neurons rescued social novelty responses in Nlgn3mice (Hörnberg et al 2020). These examples from animal experiments show that oxytocin can increase sociability and social cognition across different genetic ASD models.…”
Section: Neural Processing Of Social Odors In Asd Models and Patientsmentioning
confidence: 82%
“…The change in social behavior was dependent on an intact vagus nerve and absent in animals lacking the oxytocin receptor in dopaminergic neurons of the ventral tegmental area (Sgritta et al 2019). Also, restoration of oxytocin-signaling in the dopaminergic neurons rescued social novelty responses in Nlgn3mice (Hörnberg et al 2020). These examples from animal experiments show that oxytocin can increase sociability and social cognition across different genetic ASD models.…”
Section: Neural Processing Of Social Odors In Asd Models and Patientsmentioning
confidence: 82%
“…Oxytocin deficiency, present in the Magel2-KO mouse model and in PWS, has also been frequently described in rodent models of ASD (2). Recently, evidences for a unifying role of oxytocin in pathogenic mechanisms responsible for social impairments across abroad range of autism etiologies have been provided (67, 68). Thus, our results demonstrate that peripheral OT-administration in a critical period of time, after birth, represents a viable therapeutic strategy for patients with SYS or PWS and possibly other neurodevelopmental disorders.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, several links have been made between oxytocin signaling and autism spectrum disorder. In two different mice models, mutations in human autism risk genes resulted in impaired oxytocin signaling and autistic-like behavior [ 91 , 92 ].…”
Section: Resultsmentioning
confidence: 99%