“…Recently published solutions usually combine advanced unsupervised image segmentation algorithms with supervised and semi-supervised machine learning techniques. The wide spectrum of methodologies includes: active contour models combined with texture features [5], cellular automata combined with level sets [6], graph cut segmentation algorithm [7], superpixels combined with non-parametric classifiers [8], feature fusion combined with joint label fusion [9], texture feature and kernel sparse coding [10], Gaussian mixture models [11], [12], fuzzy cmeans clustering in semi-supervised context [13], [14], fuzzy c-means clustering combined with region growing [15], AdaBoost classifier [16], extremely random trees (ERT) [17] combined with superpixel level features [18], random forests [19], [20], [21] and ensemble of random forests [22], support vector machines [23], expert systems [24], convolutional neural network [25], [26], deep neural networks [27], [28], [29], [30], generative adversarial networks [31], and tumor growth model [32].…”