Rescuing US biomedical research from its systemic flaws

Alberts, Bruce; Kirschner, Marc W.; Tilghman, Shirley M.; Varmus, Harold

doi:10.1073/pnas.1404402111

Cited by 706 publications

(690 citation statements)

References 10 publications

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“…For institutions and individual researchers attempting to make long-term decisions, financial uncertainty makes planning very challenging. It is clear that simply putting more money into the system would provide only a temporary fix, not a long-term solution to the systemic problems with academic research ( Alberts et al , 2014; Martinson, 2007). …”

Section: Genesis Of the Future Of Research Symposiummentioning

confidence: 99%

“…Hyper-competition can also discourage creative thinking and risk-taking, strong foundations of the scientific endeavor ( Alberts et al , 2014). Rather than grant applications for innovative, breakthrough science, we have observed that hyper-competition results in “safe” applications, driving incremental, slow improvements on existing knowledge.…”

Section: Genesis Of the Future Of Research Symposiummentioning

confidence: 99%

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Shaping the Future of Research: a perspective from junior scientists

et al. 2014

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The landscape of scientific research and funding is in flux and affected by tight budgets, evolving models of both publishing and evaluation, and questions about training and workforce stability. As future leaders, junior scientists are uniquely poised to shape the culture and practice of science in response to these challenges. A group of postdocs in the Boston area who are invested in improving the scientific endeavor, planned a symposium held on October 2 nd and 3 rd, 2014, as a way to join the discussion about the future of US biomedical research. Here we present a report of the proceedings of participant-driven workshops and the organizers’ synthesis of the outcomes.

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Section: Genesis Of the Future Of Research Symposiummentioning

confidence: 99%

Section: Genesis Of the Future Of Research Symposiummentioning

confidence: 99%

Shaping the Future of Research: a perspective from junior scientists

et al. 2014

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“…1 vaccination against some infections is a discussion point further in the paper The practical goal is the elimination of disease causes, rather than employing causes of health and prevention. Indicating a further distancing of research foci from health, it has been observed that B[o]vervaluing translational research is detracting from an equivalent appreciation of fundamental research of broad applicability, without obvious connections to medicine^ [6].…”

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confidence: 99%

Risk and resistance perspectives in translation-oriented etiology research

Vanyukov

Tarter

Conway

et al. 2015

Behav. Med. Pract. Policy Res.

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Risk for a disorder and the mechanisms that determine its elevation, risk factors, are the focus of medical research. Targeting risk factors should serve the goal of prevention and treatment intervention. Risk, however, is but one of the aspects of liability to a disorder, a latent trait that encompasses effects of all factors leading to or from the diagnostic threshold. The coequal but opposite aspect of liability is resistance to a disorder. The factors that increase resistance and thus enable prevention or recovery may differ from those that elevate risk. Accordingly, there are nontrivial differences between research perspectives that focus on risk and on resistance. This article shows how this distinction translates into goals and methods of research and practice, from the choice of potential mechanisms tested to the results sought in intervention. The resistance concept also differs from those of Bresilience^and Bprotective factors,^subsuming but not limited to them. The implications of the concept are discussed using substance use disorder as an example and substantiate the need for biomedical research and its translation to shift to the resistance perspective. Keywords

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“…Over the last three decades, and despite phenomenal advances in life sciences, plant science has failed to capture the imagination of this generation's (young) scientists. Whilst the number of PhD students enrolled in biomedical research doubled between 1982 and 2012, plant science PhD enrolments flat-lined (Alberts et al 2014;Jones 2014). This is at least in part due to the much-lamented stagnation in worldwide agricultural and plant science research funding (Butler 2008).…”

Section: How To Exploit the 'Omics Revolution' For Better Food Securitymentioning

confidence: 99%

Genomic breeding for food, environment and livelihoods

2015

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Land use management is a central challenge for the 21st century with unprecedented and competing demands to produce food, feed/fodder, fibre, fuel, and essential ecosystem services which sustain life. Global change requires rapid adaptation in current and emerging crops as well as in the foundation species of natural ecosystems. Revolutions in genomics and high throughput experimentation are transforming breeding so that adaptive traits in new environments can be predicted and selected more directly from germplasm collections of crops and wild species. This genomic breeding is now feasible in almost any species and has promise to help meet the need to feed and nourish over 9 billion people by 2050. Genomic techniques can accelerate our response to food security challenges of yield, quality and resilience and also address environmental security challenges. To achieve its potential there will need to be widespread and ongoing investments in the human capital to promote genomic breeding.

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Rescuing US biomedical research from its systemic flaws

Cited by 706 publications

References 10 publications

Shaping the Future of Research: a perspective from junior scientists

Shaping the Future of Research: a perspective from junior scientists

Risk and resistance perspectives in translation-oriented etiology research

Genomic breeding for food, environment and livelihoods

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