Research advances in the regulation of the putative ovarian germline stem cell niche on female germline stem cells

Abstract

BMP: bone morphogenetic protein; Dpp: decapentaplegic; FGSC: female germline stem cell; IL, interleukin; OGSC: ovarian germline stem cells; ROS: reactive oxygen species; TGF, transforming growth factor; TNF, tumor necrosis factor.

Female germline stem cells: aging and anti-aging

“…In consideration of that FGSCs niche structure and function in mammals are less clear than that of drosophila, we believe that the mammal niche is similar to the drosophila niche. The niche of ovaries in mammals maybe includes follicular membrane-stromal cells, granulosa cells, extracellular matrix, blood vessels, immune system-related cells and cytokines [ 55 ]. Bukovsky observed that niche of FGSCs formed during early embryonic development consist of nonspecific ovarian monocyte-derived cells(MDCs), T cells, and vascular endothelial cells, whereas nests of adult ovarian germinal stem cells consist of primary CD14 + MDCs, activated HLA-DR + MDCs and T cells [ 56 ].…”

Effects of shikonin on the development of ovarian follicles and female germline stem cells

“…Female germline stem cells (FGSCs) maintain the female reproductive functions and FGSCs have been extensively studied during the stages of oogenesis. 16 The ability to isolate FGSCs and study their proliferation enables the understanding of neo-oogenesis and ovarian recession. 17 This current study explored whether SHK controls the proliferation, differentiation and apoptosis of FGSCs.…”

“…18 In addition, oxidative stress impairs the stem-cell niche and induces follicular atresia. 16 , 17 The bioactivity of superoxide dismutase (SOD) and glutathione (GSH) counteracts the oxidative cytotoxicity induced by reactive oxygen species (ROS). 16–19…”

“…16 , 17 The bioactivity of superoxide dismutase (SOD) and glutathione (GSH) counteracts the oxidative cytotoxicity induced by reactive oxygen species (ROS). 16–19…”

“…18 In addition, oxidative stress impairs the stem-cell niche and induces follicular atresia. 16,17 The bioactivity of superoxide dismutase (SOD) and glutathione (GSH) counteracts the oxidative cytotoxicity induced by reactive oxygen species (ROS). [16][17][18][19] To investigate the possible mechanism underlying the effects of SHK on ovarian follicular development and FGSCs, this current study measured the GSH concentration and the activity of SOD in the peripheral blood of mice.…”