Research advances in traditional and modern use of <i>Nelumbo nucifera</i>: phytochemicals, health promoting activities and beyond

Chen, Guilin; Zhu, Mingzhi

doi:10.1080/10408398.2018.1553846

Cited by 90 publications

(85 citation statements)

References 116 publications

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“…According to the researches on the anti-obesity effect of lotus leaves, it is found that most of the experiments in vitro introduced the extract or the isolated monomer compounds are useful for the suppression of obesity in adipocyte by inhibiting lipase activity, lipogenesis and adipocyte differentiation [15][16][17][18]. In vivo experiments, the anti-obesity effects were measured by body weight, blood lipids and liver function indicators in obese mice induced by high-fat diet [19][20][21]. However, obesity, as a chronic metabolic disease, affects systemic functions.…”

Section: Introductionmentioning

confidence: 99%

The anti-obesity effect of lotus leaves on high-fat-diet-induced obesity by modulating lipid metabolism in C57BL/6J mice

Tan

Zhang

et al. 2020

Appl Biol Chem

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Lotus leaves (Nelumbo nucifera) are widely used in medicines and foods. The investigate systematically studied the anti-obesity effect of lotus leaf extracts. It could reduce body weight, alleviate liver damage, and inhibit fat accumulation in high-fat-diet-induced obese mice. Lotus leaf extracts reduced serum alanine aminotransferase (ALT), aspartate transaminase (AST), and alkaline phosphatase (AKP) levels; decreased total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) levels in the serum; and increased high-density lipoprotein cholesterol (HDL-C) levels to improve dyslipidemia. Lotus leaves also inhibited inflammation accompanied by obesity via decreasing inflammatory cytokine interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), interferon gamma (IFN-γ), and IL-6 levels and increasing anti-inflammatory cytokine IL-4 and IL-10 levels. qPCR analysis revealed that lotus leaves upregulated peroxisome proliferator-activated receptor alpha (PPAR-α), lipoprotein lipase (LPL), carnitine palmitoyltransferase 1 (CPT1), and cholesterol 7 alpha hydroxylase (CYP7A1) mRNA expressions and downregulated peroxisome proliferator-activated receptor gamma (PPAR-γ) and CCAAT/enhancer-binding protein alpha (C/EBP-α) mRNA expressions, to reduce adipocyte differentiation and fat accumulation, promote oxidation of fat and decomposition of triglyceride and cholesterol. So, lotus leaves effectively regulated lipid metabolism, alleviated inflammation and liver injury in obese mice; thus, lotus leaves could be further developed as a food to combat obesity.

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Section: Introductionmentioning

confidence: 99%

The anti-obesity effect of lotus leaves on high-fat-diet-induced obesity by modulating lipid metabolism in C57BL/6J mice

Tan

Zhang

et al. 2020

Appl Biol Chem

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“…Now, phytochemical investigations on different parts of N. nucifera have indicated a wide spectrum of at least 255 constituents belonging to different chemical groups, including proteins, amino acids, polysaccharides, starch, flavonoids, alkaloids, essential oils, triterpenoids, steroids, and glycosides. Meanwhile, it has shown pharmacological activities, including anti-obesity, antioxidant, anti-inflammatory, cardiovascular, hepatoprotective, hypoglycemic, hypolipidemic, antitumor, memoryimproving and antiviral activities, and already applicated in health food industry and clinic uses of its single plant or herbal formulae (Chen, Zhu, and Guo 2019). Aloe vera, a plant species belonging to the genus Aloe, have been extensively studied for various therapeutic activities, including anti-bacterial, anti-viral, anti-cancer activity, as well as immunoregulative and hepatoprotective properties (Gao et al 2018).…”

Section: Third International Symposium On Phytochemicals In Medicinementioning

confidence: 99%

Third International Symposium on Phytochemicals in Medicine and Food

Bai

Xiao

2019

Critical Reviews in Food Science and Nutrition

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“…Lotus plant is widely distributed throughout East Asia, China, Australia and India, not only for holding religious significance but also well known for its nutritional and medicinal value [ 8 ]. Various studies were conducted on the isolation of natural flavonoids from lotus ( Nelumbo nucifera ) parts including seeds, leaves, flowers and rhizomes [ 9 , 10 ]. All the parts of the lotus are reported to possess a significant amount of flavonoids and exhibit convincing antioxidant activities [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Statistical Optimization of Flavonoid and Antioxidant Recovery from Macerated Chinese and Malaysian Lotus Root (Nelumbo nucifera) Using Response Surface Methodology

et al. 2021

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In this study, the combination of parameters required for optimal extraction of anti-oxidative components from the Chinese lotus (CLR) and Malaysian lotus (MLR) roots were carefully investigated. Box–Behnken design was employed to optimize the pH (X1: 2–3), extraction time (X2: 0.5–1.5 h) and solvent-to-sample ratio (X3: 20–40 mL/g) to obtain a high flavonoid yield with high % DPPHsc free radical scavenging and Ferric-reducing power assay (FRAP). The analysis of variance clearly showed the significant contribution of quadratic model for all responses. The optimal conditions for both Chinese lotus (CLR) and Malaysian lotus (MLR) roots were obtained as: CLR: X1 = 2.5; X2 = 0.5 h; X3 = 40 mL/g; MLR: X1 = 2.4; X2 = 0.5 h; X3 = 40 mL/g. These optimum conditions gave (a) Total flavonoid content (TFC) of 0.599 mg PCE/g sample and 0.549 mg PCE/g sample, respectively; (b) % DPPHsc of 48.36% and 29.11%, respectively; (c) FRAP value of 2.07 mM FeSO4 and 1.89 mM FeSO4, respectively. A close agreement between predicted and experimental values was found. The result obtained succinctly revealed that the Chinese lotus exhibited higher antioxidant and total flavonoid content when compared with the Malaysia lotus root at optimum extraction condition.

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Research advances in traditional and modern use of Nelumbo nucifera: phytochemicals, health promoting activities and beyond

Cited by 90 publications

References 116 publications

The anti-obesity effect of lotus leaves on high-fat-diet-induced obesity by modulating lipid metabolism in C57BL/6J mice

The anti-obesity effect of lotus leaves on high-fat-diet-induced obesity by modulating lipid metabolism in C57BL/6J mice

Third International Symposium on Phytochemicals in Medicine and Food

Statistical Optimization of Flavonoid and Antioxidant Recovery from Macerated Chinese and Malaysian Lotus Root (Nelumbo nucifera) Using Response Surface Methodology

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