Research advances of adipocyte differentiation in poultry

Wang, W.

doi:10.1017/s004393391900059x

Cited by 5 publications

(2 citation statements)

References 45 publications

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“…Besides, a significant amount of accumulated fat in chicken adipose tissue is the incorporated TG either from plasma VLDL or from dietary fats (portomicrons) [ 35 , 36 , 37 ] ( Figure 2 ). Studies have revealed that the expression level of three transcription factors, including PPARγ, SREBP1, and C/EBPα, was dramatically promoted through preadipocyte differentiation, indicating that they have an important role in chicken adipogenesis by affecting the expression levels of target adipogenic genes [ 31 , 38 , 39 ]. Overall, adipogenesis in chicken comprises three different stages, including adipocyte proliferation, adipocyte differentiation, and lipid accumulation inside mature adipocytes.…”

Section: Overview Of Lipid Metabolism In Chickenmentioning

confidence: 99%

Molecular Regulation of Lipogenesis, Adipogenesis and Fat Deposition in Chicken

Nematbakhsh

Chong

Selamat

et al. 2021

Genes

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In the poultry industry, excessive fat deposition is considered an undesirable factor, affecting feed efficiency, meat production cost, meat quality, and consumer’s health. Efforts to reduce fat deposition in economically important animals, such as chicken, can be made through different strategies; including genetic selection, feeding strategies, housing, and environmental strategies, as well as hormone supplementation. Recent investigations at the molecular level have revealed the significant role of the transcriptional and post-transcriptional regulatory networks and their interaction on modulating fat metabolism in chickens. At the transcriptional level, different transcription factors are known to regulate the expression of lipogenic and adipogenic genes through various signaling pathways, affecting chicken fat metabolism. Alternatively, at the post-transcriptional level, the regulatory mechanism of microRNAs (miRNAs) on lipid metabolism and deposition has added a promising dimension to understand the structural and functional regulatory mechanism of lipid metabolism in chicken. Therefore, this review focuses on the progress made in unraveling the molecular function of genes, transcription factors, and more notably significant miRNAs responsible for regulating adipogenesis, lipogenesis, and fat deposition in chicken. Moreover, a better understanding of the molecular regulation of lipid metabolism will give researchers novel insights to use functional molecular markers, such as miRNAs, for selection against excessive fat deposition to improve chicken production efficiency and meat quality.

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Section: Overview Of Lipid Metabolism In Chickenmentioning

confidence: 99%

Molecular Regulation of Lipogenesis, Adipogenesis and Fat Deposition in Chicken

Nematbakhsh

Chong

Selamat

et al. 2021

Genes

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“…Instead, oleic acid was more frequently used in chicken, representing 70% of the reports. Fatty acid was reported as a key inducer of poultry adipogenesis (Matsubara et al., 2005; Wang, 2019); accordingly, several studies used oleic acid alone without other adipogenic cocktails or even serum for chicken, duck, goose, and goat adipogenesis. Nevertheless, adding TZDs, rosiglitazone or troglitazone, further increased lipid accumulation, adipogenic enzyme activity, gene expression, and lipolysis of chicken preadipocytes, indicating that oleic acid alone is insufficient to induce differentiation into fully functional adipocytes (Cheng et al., 2016).…”

Section: Technological Review On Protocols For Adipocytes From Meat A...mentioning

confidence: 99%

Reassessment of adipocyte technology for cellular agriculture of alternative fat

Sugii

Wong

Lwin

et al. 2022

Comp Rev Food Sci Food Safe

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Alternative proteins, such as cultivated meat, have recently attracted significant attention as novel and sustainable food. Fat tissue/cell is an important component of meat that makes organoleptic and nutritional contributions. Although adipocyte biology is relatively well investigated, there is limited focus on the specific techniques and strategies to produce cultivated fat from agricultural animals. In the assumed standard workflow, stem/progenitor cell lines are derived from tissues of animals, cultured for expansion, and differentiated into mature adipocytes. Here, we compile information from literature related to cell isolation, growth, differentiation, and analysis from bovine, porcine, chicken, other livestock, and seafood species. A diverse range of tissue sources, cell isolation methods, cell types, growth media, differentiation cocktails, and analytical methods for measuring adipogenic levels were used across species. Based on our analysis, we identify opportunities and challenges in advancing new technology era toward producing “alternative fat” that is suitable for human consumption.

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