Research and Development for Optical Computer Tomography Based on Optical heterodyne Detection Scheme as a New Measurement Method of Biological Tissues and Systems

Toida, Masahiro; Kondō, Makoto; ICHIMURA, Tutomu; Inaba, Humio

doi:10.2530/jslsm1980.10.3_51

Cited by 4 publications

(1 citation statement)

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“…The configuration of a generalized coherent detection imaging (CDI) system operating in either the transmission or reflection mode is shown in figure 1. The transmission mode of CDI was proposed by the last of the present authors and coworkers (Toida et al 1989a(Toida et al , b, 1990, and implemented in the first demonstration of laser CT of tissues (Inaba et al 1990a, b, Toida et al 1991a. On the other hand, the reflection mode of CDI was introduced initially as a low-coherence reflectometry to inspect opto-electronic devices and optical fibres (Youngquist et al 1987, Takada et al 1987, Danielson and Whittenburg 1987, and has been successfully implemented in the optical imaging of tissues with micrometre resolution (Huang et al 1991, Clivaz et al 1992, Schmitt et al 1993.…”

Section: Principles Of the Coherent Detection Methodsmentioning

confidence: 92%

Coherent detection techniques in optical imaging of tissues

et al. 1997

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To form optical images from the transmitted or reflected light that is multiply scattered inside biological tissue, several detection techniques that extract the least-scattered photons or path-resolved photons have been developed. This paper reviews the coherent detection techniques. Emphasis is put on coherent detection imaging methods based on optical heterodyning, whose attractive features include quantum-noise-limited sensitivity, wide dynamic range, and excellent directionality and selectivity. Coherent detection methods have been implemented to achieve laser computed tomography and micrometre-resolution cross-sectional images in both in vivo and in vitro biological systems. Imaging works by ourselves and others are described, and an experimental study on coherent photon migration through highly scattering media is described to aid the understanding of the coherent detection method in selectively detecting the signal-carrying photons.

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Section: Principles Of the Coherent Detection Methodsmentioning

confidence: 92%

Coherent detection techniques in optical imaging of tissues

et al. 1997

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Optical computed tomography for biomedical objects based on coherent detection imaging method

Toida¹,

Ichimura

Kondō

et al. 1992

Electron Comm Jpn Pt II

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This paper summarizes a series of studies aiming at realization of computed tomography imaging (CT) by laser beam for actual in vitro biological samples, which is the first successful trial achieved in the world. The method is realized first by image reconstruction, which detects and selects only the weak transmitted light component buried in stronger multiple scattered light, using the optical heterodyne detection with a very high directivity and sensitivity. This is called coherent detection imaging (CDI). To realize the optical CT using the laser light based on the projection theorem, the following three conditions should essentially be satisfied: (1) The direct‐transmitted light component in the biological system with multiple scattering should accurately be selected and detected. (2) The Lambert‐Beer law should be applied to the selectively detected direct‐transmitted light component. (3) There must exist a direct‐transmitted light component in the medium with complex distribution of refraction index as well as complex boundaries. The authors examined the medium in which the sample is buried and cannot be observed, not only by the naked eye but also by the traditional direct detection method. It was verified experimentally that the three conditions for the realization of the optical CT are applicable, and it was demonstrated that optical CT imaging is feasible for actual samples using the CDI method.

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