The seismic safety assessment of 3D complex structural elements of historic buildings, such as cross vaults, is a challenge and experimental tests can provide relevant data for this purpose. This paper presents the results of two experimental campaigns in a reduced scale 3D printed vault characterized by asymmetric boundary conditions. The specimen adopted the typical geometry of groin vault (without ribs) and was made of polymeric bricks placed in an orthogonal bond disposition. The seismic behaviour of the vault was studied through quasi-static and dynamic tests using the shake table. In particular, an incremental dynamic analysis up to the collapse of the vault was carried out. The results obtained experimentally were analysed in terms of damage, collapse mechanisms, displacements, in-plane distortion and response spectrum-based analysis.