Research Article Synergic effect of oral contraceptives, GSTP1 polymorphisms, and high-risk HPV infection in development of cervical lesions.

Chagas, Bárbara Simas; Gurgel, Ana Pavla Almeida Diniz; Júnior, Sergio S. L. Paiva; Lima, Rafaela Carvalho Pereira; Cordeiro, Marcelo Nazário; Moura, Ronald; Coelho, Antônio Victor Campos; Nascimento, Kamylla Conceição Gomes; Neto, Jacinto da Costa Silva; Crovella, Sérgio; Freitas, Antônio Carlos de

doi:10.4238/gmr16039742

Cited by 6 publications

(6 citation statements)

References 36 publications

(38 reference statements)

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“…Our findings agreed with reports in the literature that progesterone hormones increase viral mRNA and significantly stimulate viral replication [ 39 , 64 , 65 ]. Studies on the relationship between contraceptive use and HPV infections have produced discordant findings in humans [ 27 , 55 , 66 , 67 ]. A recent study showed that contraceptives did not increase the risk of acquiring new HPV infections [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, the continuous stimulatory effect of the hormones on expression of the papillomavirus genes could also lead to an increase in expression of the viral oncogenes, i.e., E6 and E7, thereby enhancing their transforming potential. Nevertheless, most studies agree that a longer duration of contraceptive use (>5 years) can be a risk for viral persistence, a key factor for cancer development [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

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Depo Medroxyprogesterone (DMPA) Promotes Papillomavirus Infections but Does Not Accelerate Disease Progression in the Anogenital Tract of a Mouse Model

Brendle

et al. 2022

Viruses

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Contraceptives such as Depo-medroxyprogesterone (DMPA) are used by an estimated 34 million women worldwide. DMPA has been associated with increased risk of several viral infections including Herpes simplex virus-2 (HSV-2) and Human immunodeficiency virus (HIV). In the current study, we used the mouse papillomavirus (MmuPV1) anogenital infection model to test two hypotheses: (1) contraceptives such as DMPA increase the susceptibility of the anogenital tract to viral infection and (2) long-term contraceptive administration induces more advanced disease at the anogenital tract. DMPA treatments of both athymic nude mice and heterozygous NU/J (Foxn1nu/+) but ovariectomized mice led to a significantly increased viral load at the anogenital tract, suggesting that endogenous sex hormones were involved in increased viral susceptibility by DMPA treatment. Consistent with previous reports, DMPA treatment suppressed host anti-viral activities at the lower genital tract. To test the impact of long-term contraceptive treatment on the MmuPV1-infected lower genital tract, we included two other treatments in addition to DMPA: 17β-estradiol and a non-hormone based contraceptive Cilostazol (CLZ, Pletal). Viral infections were monitored monthly up to nine months post infection by qPCR. The infected vaginal and anal tissues were harvested and further examined by histological, virological, and immunological analyses. Surprisingly, we did not detect a significantly higher grade of histology in animals in the long-term DMPA and 17β-estradiol treated groups when compared to the control groups in the athymic mice we tested. Therefore, although DMPA promotes initial papillomavirus infections in the lower genital tract, the chronic administration of DMPA does not promote cancer development in the infected tissues in our mouse model.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Depo Medroxyprogesterone (DMPA) Promotes Papillomavirus Infections but Does Not Accelerate Disease Progression in the Anogenital Tract of a Mouse Model

Brendle

et al. 2022

Viruses

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“…The distribution profile of the GSTP1 A>G (rs1695) polymorphism varies according to the population, with the MAF (allele G ) ranging from 24.7% to 43% in the Brazilian population [ 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. As far as we know, there is no data on GSTP1 polymorphism frequency from other indigenous Brazilian populations focusing on mercury exposure.…”

Section: Discussionmentioning

confidence: 99%

Chronic Mercury Exposure and GSTP1 Polymorphism in Munduruku Indigenous from Brazilian Amazon

Silva

Oliveira

Vasconcellos

et al. 2023

Toxics

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Genetic polymorphisms may be involved with mercury levels and signs and symptoms of intoxication from this exposure. Therefore, the aims were to describe the frequency of the GSTP1 polymorphism and to evaluate its effects on mercury levels and neurological signs in three Munduruku indigenous villages in the Brazilian Amazon. One-hundred-and-seven indigenous (over 12 years old) were included and genotyped (rs1695) using a TaqMan validated assay. Then, associations were evaluated by binary logistic regression, using odds ratios (OR) and 95% confidence intervals (CI). Mean age was 27.4 ± 13.9 years old, 52.3% were male, mean hair mercury concentration was 8.5 ± 4.3, exceeding the reference limit (≥ 6.0 µg/g), and were different among the three villages: 13.5 ± 4.6 µg/g in Sawré Aboy, 7.4 ± 2.3 µg/g in Poxo Muybu and 6.9±3.5 µg/g in Sawré Muybu. The minor allele frequency of GSTP1 G was significantly different among the villages: 57% Sawré Muybu, 21% Poxo Muybu and 15% Sawré Aboy. Finally, after adjustment, GSTP1 GG and GA genotypes were associated with lower levels of Hg (OR = 0.13; CI95% = 0.03–0.49) and abnormal somatosensory signs (OR = 3.7; 95%IC = 1.5–9.3), respectively. In conclusion, monitoring this population is imperative to identify individuals at higher risk of developing signs of chronic mercury exposure based on the genetic profile.

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“…Globally, it is estimated that around 291 million women carry HPV DNA, of whom 32% are infected with HPV16 or HPV18, or both 11 . Sexually transmitted infection 12 , hormonal contraceptives 5 , smoking 13 , early sexual intercourse 14 , multiple sexual partners 15 , high parity 16 , early pregnancy 17 are the risk factors associated with HPV supported by highly suggestive evidence.…”

Section: Introductionmentioning

confidence: 97%

“…Human papillomaviruses (HPV) are small double-stranded, unenveloped DNA viruses that infect the stratified epithelium 1 . HPV is the central risk factor for developing cervical cancer and is the third most common cancer in women 2 – 4 .HPV is the most common viral infection of the reproductive tract and it is estimated that approximately 98% of this disease is associated with oncogenic types of HPV 5 . There are more than 200 HPV genotypes present; among the major HRHPV genotypes are HPV16, 18, 31, 33,35, 39, 45, 51, 52, 56, 58, 59, 66 and 68 6 , 7 .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of human papillomavirus infection and associated factors among women attending cervical cancer screening in setting of Addis Ababa, Ethiopia

Tesfaye,

Kumbi,

Mandefro

et al. 2024

Sci Rep

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Human papillomaviruses (HPVs) are circular, nonenveloped small double-stranded DNA viruses that infect stratified epithelium and can cause a number of life-threatening diseases. HPV is the central risk factor for developing cervical cancer and is estimated that approximately 98% of this disease is associated with oncogenic types of HPV. HPV infection leads to an estimated 266,000 cervical cancer deaths annually. Therefore, the objective of this study was to determine the prevalence of HPV infection and risk factors associated with cervical lesion among women attending the cervical cancer screening clinic at the Ethiopian Family Guidance Association, Addis Ababa. A cross-sectional study was conducted to determine the prevalence of HPV infection. Data were collected using a questionnaire and samples leftover from cervical screening were taken. The leftover swab was air dried and DNA was extracted and amplified by using a PCR. A total of 247 women were included in the study. The prevalence of HPV was 9.72% among the population studied. Of all participants, 27.13% were positive for cervical intraepithelial neoplasia-1 (CIN1). CIN1 positivity was found in half of HPV positive women. Among HPV positive women, half of them had started sexual intercourse at ages 12–17 years and 41.66% were women who gave birth at ages 12–17 years. The high prevalence of HPV and the CIN1 positive group were ages 36–57 and women with multiple sexual partners. The other groups with the highest CIN1 positive were 22.39% grade (9–12) and 20.9% primary (1–8) and uneducated women. Among HPV positive women, 83.33% had an abortion history and 80% miscarried in the first trimester. Among the CIN1 positives, 53.73% had more than two sexual partners. Among HPV positive women, half of them were users of contraception methods. In conclusion, the highest prevalence of HPV is among women who began sexual intercourse earlier and who gave birth at 12–17 years of age, have an abortion history, with MSP and oral contraceptive methods users. In addition to HPV, early pregnancy and sexual intercourse at 12–17 years of age, abortion, MSP, and oral hormonal contraceptives are factors in cervical cancer. Finally, most women do not have enough knowledge and awareness about cervical cancer and the risk factor.

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Research Article Synergic effect of oral contraceptives, GSTP1 polymorphisms, and high-risk HPV infection in development of cervical lesions.

Cited by 6 publications

References 36 publications

Depo Medroxyprogesterone (DMPA) Promotes Papillomavirus Infections but Does Not Accelerate Disease Progression in the Anogenital Tract of a Mouse Model

Depo Medroxyprogesterone (DMPA) Promotes Papillomavirus Infections but Does Not Accelerate Disease Progression in the Anogenital Tract of a Mouse Model

Chronic Mercury Exposure and GSTP1 Polymorphism in Munduruku Indigenous from Brazilian Amazon

Prevalence of human papillomavirus infection and associated factors among women attending cervical cancer screening in setting of Addis Ababa, Ethiopia

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