ABSTRACT. Human papillomavirus (HPV) infection is considered a risk factor for cervical cancer. Even if the high-risk HPV (HR-HPV) infection is necessary, environmental co-factors and genetic susceptibility also play an important role in cervical cancer development. In this study, a possible association of rs1695 GSTP1 polymorphisms, HR-HPV infection, and oral contraceptive use with cancer lesion development in women was investigated. The study population comprised 441 Brazilian women from the Northeast region including 98 HPV-infected women with high-grade squamous intraepithelial lesions, 77 HPV-infected women with lowgrade squamous intraepithelial lesions, and 266 HPV-negative women with no lesion, used as a control. Our data did not show a significant association between the GSTP1 polymorphism A/G (rs1695) and any HPV-related cervical abnormalities. However, considering the use of oral contraceptives, the GSTP1 rs1695 polymorphism was associated with higher susceptibility to the development of cervical lesions in HR-HPV-infected women. Our study suggests a synergic effect of oral contraceptive use, GSTP1 polymorphisms, and HR-HPV infection in the development of cervical lesions. Together, these risk factors may induce neoplastic transformation of the cervical squamous epithelium, setting conditions for secondary genetic events leading to cervical cancer.

Conforme dados do Censo Brasileiro da Educação Superior, em 2009 o número de alunos surdos matriculados no ensino superior chegava a 4.660. Neste contexto, a grande dificuldade dos alunos surdos que frequentam cursos de computação está nos conceitos iniciais da lógica de programação de computadores. O presente trabalho objetivou a construção de uma linguagem de programação baseada na de LIBRAS para o estudo de lógica de programação por deficientes auditivos, utilizando uma abordagem experimental, de caráter exploratório-descritivo e empregando um estudo de caso para a validação do experimento. A principal contribuição da pesquisa foi construção, avaliação e validação do framework simplificado para a criação de programas por deficientes auditivos, apoiado por uma IDE projetada para dar suporte as atividades, através de um intérprete virtual.