Research Common Mode Rejection in Conductometric Biosensor System With Differential Sensors

The article presents the results of research aimed at the creation of highly sensitive, compact and inexpensive biosensor analyzers based on differential conductometry. The main factors, which reduce the sensitivity of the measuring channel and cause the measurement errors, are considered; the measurement methods to eliminate or minimize their effect are discussed. The results of theoretical and experimental studies of conductometric converters of biosensors and measuring circuits are presented. The technical realization of these methods is proposed; the important characteristics of the sensors and the developed devices are described, as well as the outcomes obtained at their approbation.

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Solutions for enhancement of sensitivity and metrological reliability of conductometric biosensor systems

Мельник

Vasylenko

Semenycheva

et al. 2021

Eng. Res. Express

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Increasing the Sensitivity and Metrological Reliability of a Differential Conductometric Biosensor System

Мельник¹,

Borshchov²,

Dzyadevych³

et al. 2021

Teh. elektrodin.

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The differential method of conductometric measurements does not fully solve the problem of the influence of changes in the background electrical conductivity of the working buffer solutions on the results of conversion of the biosensor responses. The variation in the background electrical conductivity of the buffer solution upon addition of the highly conductive analyte acts as a common mode interference and causes the additive error. Here we present a new measurement method and structure of the device for quantification of the analytes that provide a significant decrease in the measurement error associated with a change in the background electrical conductivity caused by the introduction of the analyte to the working solution prior to the generation of the informative signal. A block diagram of the device and a vector model of the balancing process of its measuring circuit are presented. The advantages of the developed method and biosensor analyzer for application within the possible changes of the transducer parameters and measurement conditions are demonstrated. References 28, figures 4.

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Optimization of Balancing in a Bridge Measuring Circuit With a Differential Conductometric Sensor

et al. 2022

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The article is devoted to solving the problem of the occurrence of an additive error in determining local changes in the electrical conductivity of electrolyte solutions under conditions of changes in the background electrical conductivity of the measurement medium, which often occurs in biosensor and other systems with a differential pair of conductometric transducers, if their electrical parameters are not identical. The goal is to provide a deep suppression of the influence of background changes with significant differences in both reactance and active resistance in the transducers of a pair of sensor. The essence of the issue, the causes and mechanism of this type of error, as well as the methods and means of its reduction, developed earlier, are briefly considered. A diagram and description of the structure of a differential conductometric channel of a biosensor system based on an AC bridge, an algorithm for its balancing operations by controlling the module and phase of the test voltage, as well as a vector diagram of currents and voltages in the bridge circuit during this process. The balancing of the bridge has been was modeled analytically, bringing it to a quasi-equilibrium state, in which changes in the background electrical conductivity do not change its output signal. Additional operations for balancing the bridge are determined to achieve such a state with significant differences in both capacitances and active resistances in the impedances of a pair of conductometric transducers of a differential sensor. The results of experimental studies of the suppression of the influence of changes in the background electrical conductivity of a solution in a differential conductometric channel with using its computer model and experimental sample of a conductometric instrument with an electrical equivalent of a differential sensor are presented. A comparison of the results obtained and the corresponding data for balancing bridge circuits by previously developed methods is given. References 16, figures 3, tables 3.

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Research Common Mode Rejection in Conductometric Biosensor System With Differential Sensors

Cited by 3 publications

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Solutions for enhancement of sensitivity and metrological reliability of conductometric biosensor systems

Solutions for enhancement of sensitivity and metrological reliability of conductometric biosensor systems

Increasing the Sensitivity and Metrological Reliability of a Differential Conductometric Biosensor System

Optimization of Balancing in a Bridge Measuring Circuit With a Differential Conductometric Sensor

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