Research criteria for subcortical vascular dementia in clinical trials

Cerebral gray matter volume reduction in subcortical vascular mild cognitive impairment patients and subcortical vascular dementia patients, and its relation with cognitive deficits

“…The diagnosis of SVaD was on the basis of Erkinjuntti's brain imaging criteria (Erkinjuntti et al, 2000) and ADDTC (Alzheimer's Disease Diagnostic and Treatment Centers) criteria (H. C. Chui et al, 1992) for probable or possible VaD. The diagnosis of svMCI was on the basis of Erkinjuntti's brain imaging criteria (Erkinjuntti et al, 2000), Peterson's criteria (Petersen, 2004) with the following modifications which were previously described (Noh et al, 2014) cerebral GM volume reduction, cognitive deficits, SVaD, svMCI (SDMT), and Verbal Fluency Test (VFT). To ensure that SVaD patients with mild to moderate dementia were included in this study, SVaD patients whose CDR score˃2 were excluded.…”

“…The imaging markers of svMCI and SVaD include WMH and lacunes according to Erkinjuntti's brain imaging criteria (Erkinjuntti et al, 2000). WMH were defined as high-signal intensity area on T2-weighted imaging (T2WI) or fluid-attenuated inversion recovery (FLAIR) imaging, and graded according to Fazekas scale (Fazekas, Chawluk, Alavi, Hurtig, & Zimmerman, 1987).…”

“…Lacunes were defined as 3-15 mm abnormalities with signal equivalent to cerebral spinal fluid (CSF) on T2WI/Flair imaging. The Erkinjuntti's brain imaging criteria include "white matter cases" which mean severe periventricular and deep WMH and at least one lacune in deep GM or "lacunar cases" which mean multiple lacunes (˃5) in the deep GM and at least moderate WMH (Erkinjuntti et al, 2000).…”

Cognitive dysfunction associates with white matter hyperintensities and subcortical atrophy on magnetic resonance imaging of the elderly diabetes mellitus Japanese elderly diabetes intervention trial (J‐EDIT)

“…PVH was rated semiquantitatively as 0 (none), 1 (pencil thin lining: <3 mm from the edge of ventricles), 2 (smooth halo: 3-10 mm), 3 (extending cap or thick lining: 10-25 mm), 4 (large confluent: >25 mm) for three separate regions; adjacent to frontal horns (frontal caps), adjacent to the wall of the lateral ventricles (bands), and adjacent to the occipital horns (occipital caps). The overall degree of PVH was calculated by adding up the scores for the three separate compartments (range 0-24) [18,19]. The number and size of subcortical WMHs were counted in the frontal, parietal, occipital and temporal lobes, as were the number and size of hyperintensities in the basal ganglia and thalamus.…”

Analysis of Cerebral Blood Flow with Single Photon Emission Computed Tomography in Mild Subcortical Ischemic Vascular Dementia

“…Subcortical ischemic vascular dementia (SIVaD) is a relatively homogeneous subtype of vascular dementia (VaD) in which lacunar infarcts and white matter lesions (WMLs) associated with small vessel disease are the primary manifestations of brain lesions [1,2]. However, multiple lacunes and WMLs are not specific to SIVaD and may be found concomitantly in many other conditions including Parkinson's disease (PD) or even nonpathologic status.…”