Abstract. A complex model of heat supply system of building was developed by using Matlab. The model allows conducting for a wide range of research related to improving the energy efficiency of buildings. In this work the investigations of energy efficiency of several advanced insulation materials, which is characterized by different thermal characteristics, were carried out. Conclusions about the impact of the thermal protective envelope on the room thermal regime were made. Prognostic heat consumptions values of rooms with different characteristics of thermal insulation materials and main base-load envelopes were determined. Researches were conducted for the winter climatic conditions of Western Siberia: the average daily outdoor temperature is -22 °C, the amplitude of temperature oscillation is 8 °C.