Research of the influence of a new gel which contains extract of oak bark and aloe extract on the mucous membrane of oral cavity under the conditions of experimental stomatitis

Abstract

The study of the effect of a new gel containing the extract of oak bark and aloe extract on the mucous membrane of the oral cavity under the conditions of the experimental stomatitis Despite the advances in modern pharmacology, the effectiveness of most drugs for treating diseases of the mucous membrane of the oral cavity remains insufficient. Development of new complex drugs, which can affect the pathogenetic links of inflammatory diseases of the oral cavity, is currently relevant. In our opinion, the combination of a dry extract of aloe and a thick extract of oak bark in one dosage form is promising for creating a new medicinal product for the treatment of destructive inflammatory diseases of the oral cavity. Aim. To study the effect of a new gel on the morphological state of the mucous membrane of the lower lip and gums of rats under conditions of the experimental stomatitis. Materials and methods. The study of the effectiveness of the new gel was performed on the model of the experimental stomatitis. The experimental stomatitis in rats was modeled according to the standard method of a single 5-second application of a cotton swab with 10 % sodium hydroxide solution on the vestibule between the cutters of the mandible and the lower lip. The study was conducted on male rats weighing 180-220 g. Results. Animals of the intact control group had the normal state of the surface of the lower lip and gums. In animals of the control group on the background of the experimental stomatitis significant destructive effects of the cells of the inner surface of the lower lip and gums were observed. In the mucous membrane of the lower lip the surface layers of the defect were fairly dense necrotic masses, the bottom is the granulation tissue that replaces the own plate of the mucous membrane, submucosal membrane and subordinate muscle fibers. Application of Metrogil-Denta gel contributed to the partial restoration of the parameters studied. In the mucous membrane of the lower lip in the place of the previous ulcers a soft scar covered with the multilayered epithelium was visible. Unlike the control pathology, in 83.3 % of rats treated with the new gel the ulcerous lesions in the mucous membrane of the lower lip were completely healed. A rather mature loose fibrous tissue filled the former defect, the surface was completely epithelized. There were also no noticeable destructive inflammatory changes in the mucous membrane of gums of these rats, only hypertrophy of the epithelium was observed. In some rats the process of healing defects accelerated before the time of observation, there was a replacement of their mild scar and complete epithelization of the surface, while in others on the day of the experiment the structural and functional status of the mucous membrane almost completely restored. Conclusions. It has been found that the treatment with a new gel prevents development of destructive-inflammatory changes in the mucous membrane of the lower lip and gums in 83.3 % of rats, in some rats the process of healing defects accel...

Can Plant Materials Be Valuable in the Treatment of Periodontal Diseases? Practical Review

“…The astringent effect prevents minor bleeding in the mouth associated with periodontitis progression. Studies conducted by Tsubanova et al confirm the effectiveness of gel containing Aloe vera and oak bark extracts in periodontitis treatment [53][54][55]. The proven properties of oak bark extract permits the presumption that it could be an excellent adjunctive agent in periodontitis treatment (Table 2).…”