In order to enhance the safety performance of five kinds of transportation infrastructures: pavement, bridge, tunnel, side slope and ancillary, a comprehensive freeway infrastructure safety and emergency management system was built in this research. Firstly, the system framework was illustrated. Secondly, the infrastructure safety index system was built. Thirdly, according to the different characteristic of five kinds of infrastructures, comprehensive safety evaluation models were proposed in order to evaluate the safety of freeway infrastructure. Fourthly, the system of emergency management and emergency plans were expounded. Finally, the system software was implemented based on the previous modules. This system has strong practicability, which can compensate for the deficiencies of the infrastructure detection in the past and provide a new informationalized management platform for freeway management.