Visible light positioning (VLP) systems have experienced substantial revolutionary progress over the past year because they can offer great positioning accuracy without needing any additional infrastructure, as conventional radio-frequency (RF)-based systems. Received signal strength (RSS)-based VLP systems are a promising approach to many indoor positioning estimation problems, but still suffer from difficulty in providing high accuracy and reliability. A potential solution to these challenges is to combine VLP systems, and machine learning (ML) approaches to enhance the position prediction accuracy in two-dimensional (2-D) spaces, or more complex problems. In this paper, we propose a ML approach to accurately predict the 2-D indoor position of a mobile receiver (eg. an automated guided vehicles-AGV), based on the measured RSS values of 4 photodiodes (PDs) forming a star architecture. We examine and evaluate the performance of different ML learners applied to the above-described problem. The proposed ML and Neural Network (NN) methods exhibit great accuracy results in predicting the 2-D coordinates of a PD-based receiver.