In order to analyze temperature field and stress field of Co-based alloys laser cladding, the model of Co-based alloys laser cladding with preset-powder method has been made on low carbon steel substrate. The temperature field and stress field of laser cladding process was analyzed by SYSWELD software, and Experimental verification is done. The results showed that temperature field is appear to a trailing tail of comet, favorable metallurgy bonding with 12.3% dilution was obtained by scanning velocity was 4 mm/s. and instantaneous cooling rate of molten pool with 4 mm/s and 5 mm/s are increased to 1.47 times and 2.02 times of 3 mm/s. The transverse residual stress different nodes on the surface of coatings are always tensile stress, and it is almost steady, the maximum deformation is 0.34 mm at the edge of work-piece, these are consistent with experimental results. These results provide reference and guide to obtain high quality coatings.