Research on the antioxidant, wound healing, and anti-inflammatory activities and the phytochemical composition of maritime pine (Pinus pinaster Ait)

Tümen, İbrahim; Akkol, Esra Küpeli; Taştan, Hakkı; Süntar, İpek; Kurtça, Mehmet

doi:10.1016/j.jep.2017.09.009

Cited by 77 publications

(66 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, it is known that asiaticoside, a triterpene, is a major component in the extracts of Centella asiatica and is an element designated as a priority compound in the healing activity of this plant due to its antimicrobial activity and its ability to reduce lipoperoxidation levels and activate cells of the malphigian layer of the epidermis [37]. Moreover, it has been demonstrated that the essential oil of Pinus pinaster, whose main component is α-pinene, has antioxidant, anti-inflammatory, and wound repair activity, showing good tensile strength in the in vivo models; in the in vitro tests, this essential oil has shown a certain inhibitory capacity of the collagenase, elastase, and hyaluronidase enzymes, which are related to the remodeling of scars [38].…”

Section: Discussionmentioning

confidence: 99%

Wound Healing Activity of the Essential Oil of Bursera morelensis, in Mice

et al. 2020

View full text Add to dashboard Cite

Bursera morelensis is used in Mexican folk medicine to treat wounds on the skin. It is an endemic tree known as “aceitillo”, and the antibacterial and antifungal activity of its essential oil has been verified; it also acts as an anti-inflammatory. All of these reported biological activities make the essential oil of B. morelensis a candidate to accelerate the wound-healing process. The objective was to determine the wound-healing properties of B. morelensis’ essential oil on a murine model. The essential oil was obtained by hydro-distillation, and the chemical analysis was performed by gas chromatography-mass spectrometry (GC-MS). In the murine model, wound-healing efficacy (WHE) and wound contraction (WC) were evaluated. Cytotoxic activity was evaluated in vitro using peritoneal macrophages from BALB/c mice. The results showed that 18 terpenoid-type compounds were identified in the essential oil. The essential oil had remarkable WHE regardless of the dose and accelerated WC and was not cytotoxic. In vitro tests with fibroblasts showed that cell viability was dose-dependent; by adding 1 mg/mL of essential oil (EO) to the culture medium, cell viability decreased below 80%, while, at doses of 0.1 and 0.01 mg/mL, it remained around 90%; thus, EO did not intervene in fibroblast proliferation, but it did influence fibroblast migration when wound-like was done in monolayer cultures. The results of this study demonstrated that the essential oil was a pro-wound-healing agent because it had good healing effectiveness with scars with good tensile strength and accelerated repair. The probable mechanism of action of the EO of B. morelensis, during the healing process, is the promotion of the migration of fibroblasts to the site of the wound, making them active in the production of collagen and promoting the remodeling of this collagen.

show abstract

Section: Discussionmentioning

confidence: 99%

Wound Healing Activity of the Essential Oil of Bursera morelensis, in Mice

et al. 2020

View full text Add to dashboard Cite

show abstract

“…This leads to reduced functionality, elasticity, hydration, and thickness of the dermal connective tissue negative also influencing the correct formation, proliferation, and differentiation of keratinocytes from the basal layer towards an intact epidermal barrier. Typical symptomatic consequences such as wrinkle formation and sagging of the skin but also decelerated wound healing process is observed from the clinical point of view [35]. Our results show that all tested MAAs are able to inhibit collagenase in a dose dependent manner, and therefore MAAs could play a role in different phases of the wound healing process and extrinsic aging.…”

Section: Discussionmentioning

confidence: 59%

Absolute Configuration of Mycosporine-Like Amino Acids, Their Wound Healing Properties and In Vitro Anti-Aging Effects

et al. 2019

View full text Add to dashboard Cite

Mycosporine-like amino acids (MAAs) are water-soluble metabolites, reported to exhibit strong UV-absorbing properties. They have been found in a wide range of marine organisms, especially those that are exposed to extreme levels of sunlight, to protect them against solar radiation. In the present study, the absolute configuration of 14 mycosporine-like-amino acids was determined by combining the results of electronic circular dichroism (ECD) experiments and that of advanced Marfey’s method using LC-MS. The crystal structure of a shinorine hydrate was determined from single crystal X-ray diffraction data and its absolute configuration was established from anomalous-dispersion effects. Furthermore, the anti-aging and wound-healing properties of these metabolites were evaluated in three different assays namely the inhibition of collagenase, inhibition of advanced glycation end products (AGEs) and wound healing assay (scratch assay).

show abstract

“…Considering that the delay of wound healing is associated with many factors, such as nutrition, diabetes, infections, and aging, oxidative stress is believed to be one of them. Oxidative stress causes cell damage, which impedes wound epithelialization and interrupts the process (Tümen et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Preliminary screening on wound healing potential of Ocimum tenuiflorum l. using in vitro assays

Rohini¹,

Mansoureh²,

R.Al-S.³

et al. 2018

Food Res.

View full text Add to dashboard Cite

Herbal plants were used for food flavouring and food preservation and for the treatment of some illnesses. Ocimum tenuiflorum was one of the ancient herbal plants whereby its medicinal properties have been widely studied such as wound healing. Wound healing involves a sequence of recovery stages and many factors affect the wound healing process. The literature review showed that, leaves part was widely studied by researchers for its wound healing potential. The aim of this study was to screen the wound healing potential of other parts of the plants which are the stems and flowers in comparison to leaves using in vitro wound healing assays. Aqueous extraction for all the parts was done using the maceration method. The stems and flowers extracts did not show any promising wound healing effects through cell migration and angiogenesis process but showed significantly (p<0.05) higher effect via cell proliferation activity. Conversely, leaves extract have shown positive wound healing potency by significantly enhanced (p<0.05) the cell migration and angiogenesis activity. Overall, this experiment proved that the leaves own wound healing potency via cell migration and angiogenesis activity which could be beneficial in wound healing process. Thus, O. tenuiflorum leaves extract can be a favorable wound healing treatment yet, further detailed studies are required.

show abstract

Research on the antioxidant, wound healing, and anti-inflammatory activities and the phytochemical composition of maritime pine (Pinus pinaster Ait)

Cited by 77 publications

References 51 publications

Wound Healing Activity of the Essential Oil of Bursera morelensis, in Mice

Wound Healing Activity of the Essential Oil of Bursera morelensis, in Mice

Absolute Configuration of Mycosporine-Like Amino Acids, Their Wound Healing Properties and In Vitro Anti-Aging Effects

Preliminary screening on wound healing potential of Ocimum tenuiflorum l. using in vitro assays

Contact Info

Product

Resources

About