Large size TiAl alloy blade is one of the important parts to reduce the weight of advanced aero-engines. However, the precision manufacturing of such blades is a challenge due to their large size, low ductility at room temperature, and high hardness of the TiAl alloy. Electrochemical machining (ECM) is a very promising method for the precision manufacturing of such blades, considering its unique advantages. In this study, a very comprehensive multi-physical field coupling simulation and pulse ECM experiments on large size TiAl alloy blades are carried out. Geometric and theoretical models involving electric fields, gas-liquid two-phase flow, heat transfer, and anodic dissolution are developed. The variation of bubble, temperature, electrolyte flow rate, and electrical conductivity at the outlet and the different areas on the blade surface with the processing time and distribution along the flow channel in the machining gap are revealed by simulation. It is found that the influence of electrolyte temperature on electrical conductivity is more dominant than that of bubble concentration. Finally, the experiments of pulse ECM on large size TiAl alloy blade are carried out, and the experimental results are analyzed in detail. The high efficiency and high surface quality of large size TiAl alloy blades are realized. The surface roughness and machining accuracy of the blade are about Ra 0.9 μm and 0.18 mm, respectively.