Recently, in line with the increased attention paid to cultural tourism in general and to religious tourism in particular, researchers and practitioners have become increasingly interested in the analysis of various aspects related to cultural heritage in order to capitalize on its value by means of its interpretation, thus providing beneficial effects both for tourists and for tourism’s sustainable development. The aim of this research is to analyze the extent to which the methods of interpretation of the religious cultural heritage: guiding tours, quality reception, and relic worship influence the satisfaction of tourists participating in the “Saint Parascheva” pilgrimage, held annually by the Metropolitan Cathedral in Iasi. The data were collected by means of a survey (N = 932) and the information was processed by using the SPSS version 25 program. Our results indicate the significant influence that the potential to worship relics has on pilgrims’ satisfaction compared to other interpretation methods, such as the relationship with the Cathedral’s staff or the possibility of participating in guided tours. Pilgrims’ satisfaction is also perceived differently depending on certain aspects of their socio-demographic profile, i.e., their age and the perceived faith level. This study is relevant for researchers, managers, and students interested in the field of cultural heritage interpretation in genera, and in the field of religious heritage in particular, and could significantly contribute to improving pilgrims’ satisfaction as well as cultural heritage preservation.