The life and damage of hemispherical resonator are important factors that directly affect the service time and safety of high-precision hemispherical resonator gyro. However, the fused silica glass material used in the hemispherical resonator which was processed in China is mainly imported, and it is too expensive to use the traditional fatigue life experiment, so it is necessary to use the software of fatigue life analysis to analyze its fatigue life. In the paper, the ANSYS software is used to analyze the fatigue life of fused silica hemispherical resonator, to determine the dangerous parts caused by the residual stress to analyze the crack propagation in the fatigue parts, and to obtain the sum stress intensity factor, so as to effectively monitor and prevent the fatigue-prone parts in the process of structural design and use of the hemispherical resonator.