Research Progress in Calcitonin Gene-Related Peptide and Bone Repair

Wang, Qichang; Qin, Haotian; Deng, Jiapeng; Xu, Huihui; Liu, Su; Weng, Jian; Zeng, Hui

doi:10.3390/biom13050838

Cited by 14 publications

(7 citation statements)

References 136 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Factors listed have been shown to promote bone formation and/or improve fracture healing. Most factors promote osteogenic expression, although VIP has shown thus far to only inhibit OCs Molecular factor Primary receptor(s) Function in bone CGRP CLR and RAMP1 [ 38 ] ↑ osteogenic gene expression [ 38 ] SP NK-1R [ 39 ] ↑ osteocalcin and collagen expression [ 39 , 40 ] VIP VPAC1 and VPAC2 [ 41 , 42 ] ↓ OC differentiation [ 41 , 42 ] NPY Y1 [ 43 ] ↑ RUNX2 expression in MSCs [ 43 ] BDNF* TrkB [ 44 ] ↑ OPG expression [ 44 ] NGF* TrkA [ 20 , 45 ] ↑ BMP and VEGF expression [ 46 , 47 ] *Not made endogenously by peripheral nerves …”

Section: Molecular Factors In Peripheral Regulationmentioning

confidence: 99%

“…CGRP is a polypeptide primarily known for its nociceptive signaling as a neurotransmitter and as a vasodilatory, proangiogenic molecule [ 38 ]. Its main receptors are the calcitonin gene-related peptide receptor (CLR) and receptor activity modifying protein 1 (RAMP1).…”

Section: Molecular Factors In Peripheral Regulationmentioning

confidence: 99%

“…In addition to its known principal functions, CGRP can potentially bind to OBs, as OBs express CLR. This results in increased osteogenic gene expression of factors such as osteoprotegrin (OPG) [ 38 ]. The expression of CLR on OBs in conjunction with proangiogenic properties of CGRP makes it a prime candidate for improved bone healing.…”

Section: Molecular Factors In Peripheral Regulationmentioning

confidence: 99%

See 2 more Smart Citations

Do Not Lose Your Nerve, Be Callus: Insights Into Neural Regulation of Fracture Healing

Nazzal,

Morris,

Parker

et al. 2024

Curr Osteoporos Rep

View full text Add to dashboard Cite

Purpose of Review Fractures are a prominent form of traumatic injury and shall continue to be for the foreseeable future. While the inflammatory response and the cells of the bone marrow microenvironment play significant roles in fracture healing, the nervous system is also an important player in regulating bone healing. Recent Findings Considerable evidence demonstrates a role for nervous system regulation of fracture healing in a setting of traumatic injury to the brain. Although many of the impacts of the nervous system on fracture healing are positive, pain mediated by the nervous system can have detrimental effects on mobilization and quality of life. Summary Understanding the role the nervous system plays in fracture healing is vital to understanding fracture healing as a whole and improving quality of life post-injury. This review article is part of a series of multiple manuscripts designed to determine the utility of using artificial intelligence for writing scientific reviews.

show abstract

Section: Molecular Factors In Peripheral Regulationmentioning

confidence: 99%

Section: Molecular Factors In Peripheral Regulationmentioning

confidence: 99%

Section: Molecular Factors In Peripheral Regulationmentioning

confidence: 99%

See 1 more Smart Citation

Do Not Lose Your Nerve, Be Callus: Insights Into Neural Regulation of Fracture Healing

Nazzal,

Morris,

Parker

et al. 2024

Curr Osteoporos Rep

View full text Add to dashboard Cite

show abstract

“…Calcitonin gene related peptide is a members of the calcitonin family, mainly it is a nociceptive neurotransmitter acting on one of two receptors: calcitonin gene-related peptide receptor (CLR) and receptor activity modifying protein 1 (RAMP1) ( 93 ). CGRP plays a crucial role in bone fracture healing, in a study that collected plasma from patients with fracture neck of femur it was found to be highly elevated after 24 h compared to healthy controls ( 69 ).…”

Section: Growth Factors For Nerve Regenerationmentioning

confidence: 99%

Bone-nerve crosstalk: a new state for neuralizing bone tissue engineering—A mini review

Damiati,

El Soury

2024

Front. Med.

View full text Add to dashboard Cite

Neuro bone tissue engineering is a multidisciplinary field that combines both principles of neurobiology and bone tissue engineering to develop innovative strategies for repairing and regenerating injured bone tissues. Despite the fact that regeneration and development are considered two distinct biological processes, yet regeneration can be considered the reactivation of development in later life stages to restore missing tissues. It is noteworthy that the regeneration capabilities are distinct and vary from one organism to another (teleost fishes, hydra, humans), or even in the same organism can vary dependent on the injured tissue itself (Human central nervous system vs. peripheral nervous system). The skeletal tissue is highly innervated, peripheral nervous system plays a role in conveying the signals and connecting the central nervous system with the peripheral organs, moreover it has been shown that they play an important role in tissue regeneration. Their regeneration role is conveyed by the different cells' resident in it and in its endoneurium (fibroblasts, microphages, vasculature associated cells, and Schwann cells) these cells secrete various growth factors (NGF, BDNF, GDNF, NT-3, and bFGF) that contribute to the regenerative phenotype. The peripheral nervous system and central nervous system synchronize together in regulating bone homeostasis and regeneration through neurogenic factors and neural circuits. Receptors of important central nervous system peptides such as Serotonin, Leptin, Semaphorins, and BDNF are expressed in bone tissue playing a role in bone homeostasis, metabolism and regeneration. This review will highlight the crosstalk between peripheral nerves and bone in the developmental stages as well as in regeneration and different neuro-bone tissue engineering strategies for repairing severe bone injuries.

show abstract

“…[ 15 ] The sensory nerve fibers containing CGRP are distributed abundantly among bone, periosteum, epiphysis, bone marrow, and they make a strong effect on osteoblasts. [ 16 ] Because of the direct function on osteoblasts, we suspected that neuropeptides may make a certain contribution to osteophyte formation, and this is a question which has not been looked into adequately to date.…”

Section: Introductionmentioning

confidence: 99%

Relationship between knee osteophytes and calcitonin gene-related peptide concentrations of serum and synovial fluid in knee of osteoarthritis

Liu,

Su,

Zhang

et al. 2023

Medicine

View full text Add to dashboard Cite

To explore the relationship between knee osteophytes of osteoarthritic knee and calcitonin gene-related peptide (CGRP) concentrations of serum and synovial fluid (SF). 65 patients with knee medial compartment osteoarthritis (OA) were recruited and examined with weight-bearing radiographs of the entire lower limb. The concentrations of CGRP in serum/SF were also detected in surgery. The relationship between the concentrations of CGRP in serum/SF and osteophyte scores were detected with Spearman rank correlation coefficient. CGRP concentrations in serum and SF were significantly correlated with osteophyte score of overall knee respectively (R = 0.462, P < .001; R = 0.435, P < .001). In addition, a correlation tended to be observed about the relationship between CGRP concentrations in serum and SF and osteophyte scores of medial compartment (R = 0.426, P < .001; R = 0.363, P = .003), and osteophyte scores of lateral compartment (R = 0.429, P < .001; R = 0.444, P < .001). In this study, the relationship between CGRP in serum/SF and knee osteophyte scores in different subregions were explored, which showed significant positive correlations, that possibly reflecting the contribution of CGRP influencing osteophyte formation. Positive correlations between osteophyte scores and CGRP suggest that CGRP promote the growth of osteophyte formation. It has the potential to be selected as a biomarker for the assessment of severity in knee OA patients and predict the progression of knee OA. It also provides a potential therapeutic target to delay the progression and relieve the symptom of OA.

show abstract

Research Progress in Calcitonin Gene-Related Peptide and Bone Repair

Cited by 14 publications

References 136 publications

Do Not Lose Your Nerve, Be Callus: Insights Into Neural Regulation of Fracture Healing

Do Not Lose Your Nerve, Be Callus: Insights Into Neural Regulation of Fracture Healing

Bone-nerve crosstalk: a new state for neuralizing bone tissue engineering—A mini review

Relationship between knee osteophytes and calcitonin gene-related peptide concentrations of serum and synovial fluid in knee of osteoarthritis

Contact Info

Product

Resources

About