Research progress in endothelial cell injury and repair

Abstract

Endothelial cells, which are important metabolic and endocrine cells, play an important role in regulating vascular function. The occurrence and development of various cardiovascular and cerebrovascular diseases are associated with endothelial dysfunction. However, the underlying mechanism of vascular endothelial injury is not fully understood. It has been reported that the mechanism of endothelial injury mainly involves inflammation and oxidative stress. Moreover, endothelial progenitor cells are regarded as important contributors in repairing damaged endothelium. Multiple interventions (including chemical drugs and traditional Chinese medicines) exert endothelial protection by decreasing the release of inducing factors, suppressing inflammation and oxidative stress, and preventing endothelial cell senescence.

HPLC‐MS/MS Profiles, Antioxidant, Neuroprotective, Antidiabetic and Skin Protective Effects of Different Extracts of Vicia peregrina L. Collected from the Eastern Region of Turkey

“…For example, catechin has anti‐microbial, anti‐viral, anti‐inflammatory, anti‐allergenic, and anti‐cancer activities [27] . chlorogenic acid has anti‐inflammatory and antioxidant activities [28] . Delphindin glucoside possesses anticancer activity [29] .…”

“…[27] chlorogenic acid has anti-inflammatory and antioxidant activities. [28] Delphindin glucoside possesses anticancer activity. [29] Hyperoside was shown to prevent cancer and protect the brain, neurons, heart, kidneys, lung, blood vessels, bones, joints and liver.…”

A Non-Coronary, Peripheral Arterial Atherosclerotic Disease (Carotid, Renal, Lower Limb) in Elderly Patients—A Review: Part I—Epidemiology, Risk Factors, and Atherosclerosis-Related Diversities in Elderly Patients

“…Metabolic comorbidities, such as hypertension, diabetes mellitus, and dyslipidemia, are common risk factors for unfavorable vascular events. The evidence shows that early behavioral and medical intervention could halt early atherosclerotic changes, vascular stiffening, and remodeling, as well as restore endothelial function, provided that the best medical care is offered to the patient [ 193 , 194 , 195 ]. Conversely, young patient age causes serious delays in undertaking decisions on the treatment initiation.…”

Ендотеліальна Дисфункція Як Ланка Патогенезу Хронічних Запальних Дерматозів

“…Основне завдання ендотелію полягає у збалансованому виділенні біологічно активних речовин, що визначають цілісну роботу системи кровообігу. До факторів ризику пошкодження ендотелію відносяться гіперхолестеринемія, гіпергомоцистеїнемія, підвищений рівень цитокінів (інтерлейкінів-1β та -8, фактору некрозу пухлини альфа) [8]. Нині накопичено дані про багатогранність механізмів участі ендотелію у виникненні та розвитку різних патологічних станів.…”