Research progress of anti-adhesion polymeric barrier: Focusing on adhesion mechanism and corresponding modification methods

Wang, Mengjiao; Jiao, Yongjie; Li, Chaojing; Huang, Chao; Wu, Xinkang; Wang, Fujun; Wu, Jianying; Wang, Lu

doi:10.1016/j.eurpolymj.2023.112364

Cited by 4 publications

(2 citation statements)

References 94 publications

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“…Tissue fluid leakage and bleeding are common problems after the laminectomy, recruiting inflammatory cells and fibroblasts, and finally leading to tissue adhesion. 58 Therefore, in the clinic, drainage and hemostatic drugs are considered good methods to prevent postoperative adhesion. 19 If the physical barrier can prevent leakage, it will relieve the adhesion level.…”

Section: Resultsmentioning

confidence: 99%

Organism-Inspired Antioxidant Bioadhesive with Strong Sealing Ability to Prevent Epidural Adhesion

Gong,

Zhu,

Chen

et al. 2024

ACS Nano

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Epidural adhesion or epidural fibrosis is the major reason for postoperative pain, which remains a clinically challenging problem. Current physical barriers fail to provide a satisfactory therapeutic outcome mainly due to their lack of adhesion, inability to prevent fluid leakage, and exhibiting limited antioxidant properties. Herein, we fabricated a cysteine-modified bioadhesive (SECAgel) with improved sealing and antioxidant properties for epidural adhesion prevention, inspired by the organism's antioxidant systems. The resulting SECAgel showed good injectability and in situ adhesion ability, effectively covering every corner of the irregular wound. Besides, it possessed efficient sealing properties (395.2 mmHg), effectively stopping blood leakage in the rabbit carotid artery transection model. The antioxidant experiments demonstrated that the SECAgel effectively scavenged various radicals and saved the cells from oxidative stress. Two animal models were used to show that the SECAgel effectively inhibited adhesion in both situations with and without cerebrospinal fluid leakage. The RNA sequencing analysis showed that SECAgel treatment effectively inhibited the expression of key genes related to adhesion development, inflammatory response, and oxidative stress. The SECAgel, together with good biocompatibility, can be a good candidate for preventing epidural adhesion in the clinic.

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Section: Resultsmentioning

confidence: 99%

Organism-Inspired Antioxidant Bioadhesive with Strong Sealing Ability to Prevent Epidural Adhesion

Gong,

Zhu,

Chen

et al. 2024

ACS Nano

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show abstract

“…85,86 These therapeutic agents operate through diverse mechanisms, including the induction of fibroblast apoptosis, inhibition of DNA replication, transcription, and translation, antiinflammatory and antioxidant activities, hemostasis, suppression of fibrous tissue-inducing growth factors, and modulation of the blood circulation, all aimed at preventing adhesion formation. 73,87 Depending on the formation mechanism of different tissue adhesions, we can choose the appropriate therapeutic agents for the preparation of anti-adhesion materials.…”

Section: Single-layer Nanofibrous Membranesmentioning

confidence: 99%

Advanced postoperative tissue antiadhesive membranes enabled with electrospun nanofibers

Zhu,

Zhang,

Liang

et al. 2024

Biomater. Sci.

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Engineering injectable bioadhesives with sealing and anti-fouling properties for postoperative anti-adhesion

Gong,

Li,

Zhu

et al. 2024

Chemical Engineering Journal

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Research progress of anti-adhesion polymeric barrier: Focusing on adhesion mechanism and corresponding modification methods

Cited by 4 publications

References 94 publications

Organism-Inspired Antioxidant Bioadhesive with Strong Sealing Ability to Prevent Epidural Adhesion

Organism-Inspired Antioxidant Bioadhesive with Strong Sealing Ability to Prevent Epidural Adhesion

Advanced postoperative tissue antiadhesive membranes enabled with electrospun nanofibers

Engineering injectable bioadhesives with sealing and anti-fouling properties for postoperative anti-adhesion

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