2022
DOI: 10.3389/fimmu.2022.810539
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Research Progress of Biomarkers for Immune Checkpoint Inhibitors on Digestive System Cancers

Abstract: Immunotherapy represented by immune checkpoint inhibitors has gradually entered a new era of precision medicine. In view of the limited clinical benefits of immunotherapy in patients with digestive system cancers, as well as the side-effects and high treatment costs, development of biomarkers to predict the efficacy of immune therapy is a key imperative. In this article, we review the available evidence of the value of microsatellite mismatch repair, tumor mutation burden, specific mutated genes or pathways, P… Show more

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Cited by 7 publications
(6 citation statements)
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“…The results show that the assessment of PD-L1 by the CPS method is a more sensitive biomarker than the assessment by the TPS method in CRC [18,19]. These results suggest that the expression assessment in tumor cells alone may not reflect the overall immune tolerance in the tumor [18]. With many tumor-infiltrating lymphocytes (TILs), the CPS values are more significant at >50% compared to little or no tumor infiltration, which is in agreement with previously published studies [20,21].…”
Section: Discussionsupporting
confidence: 90%
See 1 more Smart Citation
“…The results show that the assessment of PD-L1 by the CPS method is a more sensitive biomarker than the assessment by the TPS method in CRC [18,19]. These results suggest that the expression assessment in tumor cells alone may not reflect the overall immune tolerance in the tumor [18]. With many tumor-infiltrating lymphocytes (TILs), the CPS values are more significant at >50% compared to little or no tumor infiltration, which is in agreement with previously published studies [20,21].…”
Section: Discussionsupporting
confidence: 90%
“…The results show that the assessment of PD-L1 by the CPS method is a more sensitive biomarker than the assessment by the TPS method in CRC [18,19]. These results suggest that the expression assessment in tumor cells alone may not reflect the overall immune tolerance in the tumor [18].…”
Section: Discussionmentioning
confidence: 90%
“…Some advanced cancers have been treated better with immune checkpoint inhibitors (ICIs) [ 40 ]. Boxplots, based on 47 immune checkpoints obtained from the literature [ 41 , 42 ], were used to illustrate the differential expression of immune checkpoints in high-risk and low-risk groups.…”
Section: Methodsmentioning
confidence: 99%
“…Digestive system cancers are one of the most common leading causes of cancer deaths worldwide, with high morbidity and mortality (85). It is difficult to detect cancers at an early stage due to lack of effective biomarkers (86).…”
Section: Expression Of Lima1 and Its Regulatory Mechanisms In Digesti...mentioning
confidence: 99%