Research Progress on MXenes: Preparation, Property and Application in Tumor Theranostics

Bai, Zhiqiang; Zhao, Lu; Bai, Yunfeng; Feng, Feng

doi:10.15541/jim20210299

Journal of Inorganic Materials

2022

DOI: 10.15541/jim20210299

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Research Progress on MXenes: Preparation, Property and Application in Tumor Theranostics

Zhiqiang Bai¹,

Lu Zhao²,

Yunfeng Bai³

et al.

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2023

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Cited by 2 publications

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Nanoheterojunction Engineering Enables NIR‐II‐Triggered Photonic Hyperthermia and Pyroelectric Catalysis for Tumor‐Synergistic Therapy

Zhang

Shi

et al. 2023

Adv Funct Materials

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Photodynamic therapy (PDT) as a non-invasive strategy shows high promise in cancer treatment. However, owing to the hypoxic tumor microenvironment and light irradiation-mediated rapid electron-hole pair recombination, the therapeutic efficacy of PDT is dramatically discounted by limited reactive oxygen species (ROS) generation. Herein, a multifunctional theranostic nanoheterojunction is rationally developed, in which 2D niobium carbide (Nb 2 C) MXene is in situ grown with barium titanate (BTO) to generate a robust photo-pyroelectric catalyst, termed as BTO@Nb 2 C nanosheets, for enhanced ROS production, originating from the effective electron-hole pair separation induced by the pyroelectric effect. Under the second nearinfrared (NIR-II) laser irradiation, Nb 2 C MXene core-mediated photonic hyperthermia regulates temperature variation around BTO shells facilitating the electron-hole spatial separation, which reacts with the surrounding O 2 and H 2 O molecules to yield toxic ROS, achieving a synergetic effect by means of combinaterial photothermal therapy with pyrocatalytic therapy. Correspondingly, the engineered BTO@Nb 2 C composite nanosheets feature benign biocompatibility and high antitumor efficiency with the tumorinhibition rate of 94.9% in vivo, which can be applied as an imaging-guided real-time non-invasive synergetic dual-mode therapeutic nanomedicine for efficient tumor nanotherapy.

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Nanoheterojunction Engineering Enables NIR‐II‐Triggered Photonic Hyperthermia and Pyroelectric Catalysis for Tumor‐Synergistic Therapy

Zhang

Shi

et al. 2023

Adv Funct Materials

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Fabricating Aptamer-functionalized Ti3C2 therapeutic nanoplatform for targeted chemo-photothermal therapy of cancer

Bai¹,

Zhao²,

Feng³

et al. 2023

Materials & Design

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Research Progress on MXenes: Preparation, Property and Application in Tumor Theranostics

Cited by 2 publications

References 82 publications

Nanoheterojunction Engineering Enables NIR‐II‐Triggered Photonic Hyperthermia and Pyroelectric Catalysis for Tumor‐Synergistic Therapy

Nanoheterojunction Engineering Enables NIR‐II‐Triggered Photonic Hyperthermia and Pyroelectric Catalysis for Tumor‐Synergistic Therapy

Fabricating Aptamer-functionalized Ti3C2 therapeutic nanoplatform for targeted chemo-photothermal therapy of cancer

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