Research Progress on the Anti-Aging Potential of the Active Components of Ginseng

Abstract

Aging is a cellular state characterized by a permanent cessation of cell division and evasion of apoptosis. DNA damage, metabolic dysfunction, telomere damage, and mitochondrial dysfunction are the main factors associated with senescence. Aging increases β-galactosidase activity, enhances cell spreading, and induces Lamin B1 loss, which further accelerate the aging process. It is associated with a variety of diseases, such as Alzheimer’s disease, Parkinson’s, type 2 diabetes, and chronic inflammation. Ginseng is a traditional Chinese medicine with anti-aging effects. The active components of ginseng, including saponins, polysaccharides, and active peptides, have antioxidant, anti-apoptotic, neuroprotective, and age-delaying effects. DNA damage is the main factor associated with aging, and the mechanism through which the active ingredients of ginseng reduce DNA damage and delay aging has not been comprehensively described. This review focuses on the anti-aging mechanisms of the active ingredients of ginseng. Furthermore, it broadens the scope of ideas for further research on natural products and aging.

Role of traditional Chinese medicine in age-related macular degeneration: exploring the gut microbiota’s influence

“…Ginseng , derived from the desiccated root and rhizome of Panax ginseng C. A. Meyer, a member of the Wujiaceae family, possesses several health benefits. It comprises a diverse range of active components, including ginsenosides, polysaccharides, and volatile oils ( Su et al, 2023 ; Zhou et al, 2023 ), significantly affecting immunity, oxidative stress, inflammation, apoptosis, and coagulation ( Zhou et al, 2023 ). Lee et al (2015) utilized the ginsenoside targeted transport pathway to improve nutrient exchange in Bruch’s membrane of human donors, delaying its aging and preventing the onset and progression of AMD.…”

Cutaneous Redox Senescence

“…It is already known that vitamins that act as skin antioxidants are mainly taken from food [93,187]. Furthermore, foods such as Ginseng [188], the seed of Prunus mume [189], in addition to the consumption of probiotics and prebiotics [190], have demonstrated efficiency in modulating the endogenous antioxidant capacity of the skin, reducing oxidative damage and, consequently, aging and/or senescence. These studies indicate that, in addition to the topical use of synthetic or natural formulas, a complementary strategy should be promoted for the consumption of functional foods to combat senescence and aging [191].…”

The pharmaceutical effect of Korean wild ginseng residue extract on the performance, microbiota quality, cytokine expression, and the ginseng saponin content of laying hen

“…Phytogenic such as wild ginseng ( WG ) contains bioactive compounds which include ginseng saponin ( GS ), lignans, peptides, polyacetylenes, and alkaloids, making it a potent source of traditional medications for centuries in the Eastern part of Asia due to its multifaceted immune and energy boosting ability with anti-oxidative and anti-inflammatory capacity ( Yan et al, 2011 ; Peng et al, 2023 ). This antioxidant and anti-inflammatory activity is vital for cellular health and may contribute to ginseng's reported anti-aging effects, and has been proven to improve performance ( Su et al, 2023 ; Tajudeen et al, 2023 ). Thus, serving as a viable alternative to antibiotics.…”