Research Progress on the Antiosteoarthritic Mechanism of Action of Natural Products

Gao, Mingyang; Chen, Chun; Zhang, Qiaoyan; Bian, Jun; Qin, Lu‐Ping; Bao, Leilei

doi:10.1155/2021/7714533

Cited by 6 publications

(8 citation statements)

References 99 publications

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“… 18 , 19 Natural products, including terpenoids, polysaccharides, polyphenols, flavonoids, alkaloids, and saponins, are advantageous as their low toxicity, low costs, and act on multiple targets, are gradually being applied in the treatment of OA. 20 But, the function of AC tissue is largely conferred by its compartmentalized zonal microstructure and composition.…”

Section: Articulate Cartilage Defects Therapeutic Strategiesmentioning

confidence: 99%

Regeneration of articular cartilage defects: Therapeutic strategies and perspectives

Guo

Ling

et al. 2023

J Tissue Eng

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Articular cartilage (AC), a bone-to-bone protective device made of up to 80% water and populated by only one cell type (i.e. chondrocyte), has limited capacity for regeneration and self-repair after being damaged because of its low cell density, alymphatic and avascular nature. Resulting repair of cartilage defects, such as osteoarthritis (OA), is highly challenging in clinical treatment. Fortunately, the development of tissue engineering provides a promising method for growing cells in cartilage regeneration and repair by using hydrogels or the porous scaffolds. In this paper, we review the therapeutic strategies for AC defects, including current treatment methods, engineering/regenerative strategies, recent advances in biomaterials, and present emphasize on the perspectives of gene regulation and therapy of noncoding RNAs (ncRNAs), such as circular RNA (circRNA) and microRNA (miRNA).

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Section: Articulate Cartilage Defects Therapeutic Strategiesmentioning

confidence: 99%

Regeneration of articular cartilage defects: Therapeutic strategies and perspectives

Guo

Ling

et al. 2023

J Tissue Eng

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“…Obesity can lead to joint overload and promote OA development. In addition, mechanical damage to articular cartilage and subchondral bone promotes OA development ( Balahura et al, 2020 ; Gao et al, 2021 ). Part of OA is attributable to inheritance, with hereditary OA due to mutations in collagen type II, IX, or XI ( Kannu et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

“…Studies have found that natural products could regulate glycolysis ( Duya et al, 2022 ; Kooshki et al, 2022 ), interfere with chondrocyte metabolic reprogramming, improve chondrocyte viability, and inhibit OA development. Moreover, natural products have the advantages of low toxicity, low cost and multiple targets ( Gao et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

A new strategy for osteoarthritis therapy: Inhibition of glycolysis

Tan

Han

et al. 2022

Front. Pharmacol.

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Osteoarthritis (OA) is a common degenerative disease of the joints. It is primarily caused by age, obesity, mechanical damage, genetics, and other factors, leading to cartilage degradation, synovial inflammation, and subchondral sclerosis with osteophyte formation. Many recent studies have reported that glycolysis disorders are related lead to OA. There is a close relationship between glycolysis and OA. Because of their hypoxic environment, chondrocytes are highly dependent on glycolysis, their primary energy source for chondrocytes. Glycolysis plays a vital role in OA development. In this paper, we comprehensively summarized the abnormal expression of related glycolytic enzymes in OA, including Hexokinase 2 (HK2), Pyruvate kinase 2 (PKM2), Phosphofructokinase-2/fructose-2, 6-Bisphosphatase 3 (PFKFB3), lactate dehydrogenase A (LDHA), and discussed the potential application of glycolysis in treating OA. Finally, the natural products that can regulate the glycolytic pathway were summarized. Targeting glucose transporters and rate-limiting enzymes to glycolysis may play an essential role in treating OA.

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“…Results from studies using herbal and plant extracts to manage OA are encouraging and may provide greater flexibility in clinical settings ( Gao et al, 2021 ; Mu et al, 2021 ). Ginkgo biloba L. extract is widely used worldwide as the first choice botanical medicine for the treatment of heart and brain diseases ( Abad et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Ginkgolide C slows the progression of osteoarthritis by activating Nrf2/HO-1 and blocking the NF-κB pathway

Jia

Zhao³

et al. 2022

Front. Pharmacol.

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Osteoarthritis (OA) is driven by chronic low-grade inflammation and subsequent cartilage degradation. OA is the most prevalent degenerative joint disease worldwide, and its treatment remains a challenge. The aim of this study was to explore the potential effects and mechanism underlying the anti-OA properties of ginkgolide C (GC). Protective effects of GC on hydrogen peroxide (H2O2)-treated rat chondrocytes were evaluated using ELISA, qPCR, western blot analysis, flow cytometry, ROS detection and immunofluorescence in vitro. Ameliorating effects of GC on cartilage degeneration in rats were evaluated through behavioral assays, microcomputed tomography, histopathological analysis, western blot analysis and ELISA in vivo. In vitro, GC treatment inhibited the release of pro-apoptotic factors induced by H2O2 and promoted the release of the anti-apoptotic proteins. In addition, GC decreased the expression of matrix metalloproteinase (MMP3 and MMP13), thrombospondin motifs 4 (ADAMTS4), and inflammatory mediators inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2), and SOX9 thereby inhibiting extracellular matrix (ECM) degradation. Mechanistically, GC exerts its anti-apoptotic and anti-inflammatory effects by upregulating the oxidative stress signaling Nrf2/HO-1 pathway and preventing p65 from binding to DNA. Similarly, In a rat model with post-traumatic OA (PTOA) induced by anterior cruciate ligament transection (ACLT), GC inhibited joint pain, cartilage destruction, and abnormal bone remodeling of subchondral bone. GC inhibited H2O2-induced chondrocyte apoptosis through Nrf2/HO-1 and NF-κB axis, exerted anti-inflammatory effects, and inhibited cartilage degeneration in rat OA. Our findings advanced the concept that GC may contribute to cartilage metabolism through anti-inflammatory and anti-apoptotic effects, and the identified GC is a potential therapeutic agent for the treatment of OA.

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Research Progress on the Antiosteoarthritic Mechanism of Action of Natural Products

Cited by 6 publications

References 99 publications

Regeneration of articular cartilage defects: Therapeutic strategies and perspectives

Regeneration of articular cartilage defects: Therapeutic strategies and perspectives

A new strategy for osteoarthritis therapy: Inhibition of glycolysis

Ginkgolide C slows the progression of osteoarthritis by activating Nrf2/HO-1 and blocking the NF-κB pathway

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