Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke

Li, Lei; Yang, Shuaifeng; Lü, Xin; Zhang, Yongfa; Li, Tao

doi:10.3389/fnagi.2021.698601

Cited by 16 publications

(8 citation statements)

References 111 publications

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“…In the field of ischemic stroke and autophagy, through the econometric analysis of the literature published in the past decade, we found that both BNIP3 and LC3 are research hot spots and their interactions play a key role in nonselective autophagy after ischemic stroke. Mitochondrial BNIP3 binds to autophagosome LC3 to regulate cell death in ischemic stroke [36][37][38]. Mitochondrial dysfunction during ischemic stroke affects the level of autophagy, involving metabolic imbalance, oxidative stress, apoptosis, endoplasmic reticulum stress, and many other aspects, which may provide inspiration for the development of new targeted therapies for ischemic stroke [39][40][41][42][43][44][45].…”

Section: Related Workmentioning

confidence: 99%

[Retracted] A Bibliometric Analysis for Global Trends and Full View of the Autophagy in Ischemic Stroke from 2006 to 2022

Song

Yuan

et al. 2022

BioMed Research International

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Autophagy plays a key role in ischemic stroke, but its mechanism remains to be elucidated. In order to explore the effect of autophagy on ischemic stroke, bibliometric analysis and view tools are used to identify the directions of the global research trends and construct full view of the autophagy in ischemic stroke from 2006 to 2022. The research hotspots of autophagy related to ischemic stroke are visually analyzed and generated various visual maps to display publications, authors, sources, countries, organizations, and keywords. By bibliometric analysis, it can be seen that the investigations of autophagy in ischemic stroke is focused on both brain injury and neuroprotection. The impact of a variety of inflammatory factors and signaling pathways on autophagy following an ischemic stroke is also studied. Autophagy plays an important role in all phases of ischemic stroke. It is of great significance to guide the development of treatment plans for ischemic stroke.

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Section: Related Workmentioning

confidence: 99%

[Retracted] A Bibliometric Analysis for Global Trends and Full View of the Autophagy in Ischemic Stroke from 2006 to 2022

Song

Yuan

et al. 2022

BioMed Research International

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“…The oxidation method increases eggshell membrane solubility primarily by oxidizing the disulfide bonds between the fibers to sulfonic acid groups, thereby exposing more soluble fibrin to the solvent ( 53 ). The more effective oxidizing agent currently available is sodium dodecyl sulfate (SDS).…”

Section: Advances In Eggshell Membrane Proteolysis Technologymentioning

confidence: 99%

Advances in eggshell membrane separation and solubilization technologies

et al. 2023

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Eggshell membranes (ESM) contain 90% protein, 3% lipids, 2% sugars, and small amounts of minerals such as calcium and magnesium. Of the 90% of proteins present, 472 proteins species have been identified. ESM provide the initial mineralization platform for eggshell formation, and can be used for to produce adsorbents, cosmetics, and medical products because of their special physical structure and chemical composition. The special physical structure of the eggshell membrane, with disulfide bonds between and within the protein molecules and the cross-linking of lysine-derived and heterochain chains between the eggshell membrane, makes the membrane very difficult to dissolve, with a maximum solubility rate of only 62%. Also, the insolubility of ESM limits its development and use also any related research. Based on the physical structure and chemical composition of the eggshell membrane, this paper reviews the latest research on eggshell membrane separation and membrane protein solubilization to provide a reference for promoting the separation, dissolution, and rational development and use of the avian eggshell membrane.

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“…Mitochondrial dysfunction, including the overproduction of ROS, uncontrolled mitochondrial autophagy, and abnormal fission and fusion have been implicated in ischemic stroke ( Yang et al, 2018 ; Lei et al, 2021 ; Shi et al, 2022b ) . In addition, apoptosis, ATP disruption, calcium buildup, and faulty mitochondrial biogenesis contribute to aberrant ROS production during ischemic stroke ( Bai et al, 2021 ).…”

Section: The Nlrp3 Inflammasome and Its Function In Ischemic Strokementioning

confidence: 99%

Pharmacological intervention of curcumin via the NLRP3 inflammasome in ischemic stroke

Du,

Amin,

et al. 2023

Front. Pharmacol.

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Ischemic-induced neuronal injury arises due to low oxygen/nutrient levels and an inflammatory response that exacerbates neuronal loss. NOD-like receptor family pyrin domain-containing 3 (NLRP3) is an important regulator of inflammation after ischemic stroke, with its inhibition being involved in nerve regeneration. Curcumin, a main active ingredient in Chinese herbs, plays a positive role in neuronal repair and neuroprotection by regulating the NLRP3 signaling pathway. Nevertheless, the signaling mechanisms relating to how curcumin regulates NLRP3 inflammasome in inflammation and neural restoration following ischemic stroke are unknown. In this report, we summarize the main biological functions of the NLRP3 inflammasome along with the neuroprotective effects and underlying mechanisms of curcumin via impairment of the NLRP3 pathway in ischemic brain injury. We also discuss the role of medicinal interventions that target the NLRP3 and potential pathways, as well as possible directions for curcumin therapy to penetrate the blood–brain barrier (BBB) and hinder inflammation in ischemic stroke. This report conclusively demonstrates that curcumin has neuroprotective properties that inhibit inflammation and prevent nerve cell loss, thereby delaying the progression of ischemic brain damage.

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Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke

Cited by 16 publications

References 111 publications

[Retracted] A Bibliometric Analysis for Global Trends and Full View of the Autophagy in Ischemic Stroke from 2006 to 2022

[Retracted] A Bibliometric Analysis for Global Trends and Full View of the Autophagy in Ischemic Stroke from 2006 to 2022

Advances in eggshell membrane separation and solubilization technologies

Pharmacological intervention of curcumin via the NLRP3 inflammasome in ischemic stroke

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