Research Progress on the Relationship Between Oral Microbial Community and Tumor

Abstract

Significant progress was observed in studies of the relationship between oral Helicobacter pylori and gastric cancer and tumors. Based on three distinct and close relationships, namely, the relationship between oral H. pylori and gastric cancer, between oral microbial communities and oral squamous cell carcinoma, and between oral microbial communities of human immunodeficiency virus-infected patients and tumors, this work reviews the relationship between oral microbial communities and tumors. This research also provides reference for further analysis of the relationship between oral microorganisms and tumors to realize early diagnosis of tumor patients through detecting oral microorganisms under adjuvant therapy.

Oral microbiota in oral cancer patients and healthy individuals: A scoping review

“…Chemokines can promote cell migration and invasion by inducing the proliferation of cancer cells and preventing their apoptosis. [13][14][15][16] Although compelling evidence showed that carcinogenesis can be modulated by microbiota, specifically an association between microbiota in the oral cavity with oral cancer, its composition and diversity in oral cancer patients remain unclear. A big question remains: what are the oral microbiota composition and diversity found in oral cancer patients that may influence an individual's oral cancer risk?…”