Background and Objective: Immunization holds profound research significance and promising application potential in the realm of head and neck squamous cell carcinoma (HNSCC). Regrettably, only a paucity of bibliometric data has been dedicated to a systematic examination of this domain. The present study endeavors to holistically assess the research landscape encompassing immunization and allied concepts in HNSCC. It shall encompass an exhaustive review of countries, institutions, authors, and journals involved in this sphere, while also evaluating the knowledge framework through keyword co-occurrence analysis. Methods: The method employed for subject retrieval involved accessing the Web of Science core collection to obtain works and reviews concerning HNSCC immunity. Subsequently, bibliometric analysis was conducted utilizing the Cite Space and VOS viewer software. Results: Between 1 January 2012 and 31 October 2022, a total of 1,744 English works and reviews were considered in the analysis. The research contributions emanated from 402 institutions, primarily from 57 countries and regions. In terms of journals, CANCERS published the highest number of works, other journals in the fields of molecular biology, biological immunology, and clinical medicine also made substantial contributions. Over the course of time, the landscape of research hotspots gracefully evolved. Certain illustrious terms such as “open label”, “t cell”, “immunotherapy”, and “tumor microenvironment” elegantly emerged, gracing the scholarly stage with their profound frequency. Conclusion: This study presents a thorough and all-encompassing assessment of HNSCC research within the context of immunity, achieved through the utilization of bibliometric and visualization methodologies. By offering insights into the dynamic evolution of immune-related concepts in HNSCC, this paper will undoubtedly aid researchers in gaining a deeper understanding of this complex domain.