Residual vein thrombosis and serial D-dimer for the long-term management of patients with deep venous thrombosis

Prandoni, Paolo; Vedovetto, Valentina; Ciammaichella, Maurizio; Bucherini, Eugenio; Corradini, Sara; Enea, Iolanda; Cosmi, Benilde; Mumoli, Nicola; Visonà, Adriana; Barillari, Giovanni; Bova, Carlo; Quintavalla, Roberto; Zanatta, Nello; Pedrini, Simona; Villalta, Sabina; Camporese, Giuseppe; Testa, S.; Parisi, Roberto; Becattini, Cecilia; Cuppini, Stefano; Pengo, Vittorio; Palareti, Gualtiero; Investigators, Morgagni

doi:10.1016/j.thromres.2017.04.002

Cited by 28 publications

(20 citation statements)

References 31 publications

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“…This conclusion was partly supported by another multicenter cohort study involving 410 subjects, which concluded that the risk of VTE recurrence in patients with negative D‐dimer level is low enough to justify stopping the therapy in women but may be not low enough in men . This finding revealed that a negative D‐dimer level may not be safe enough to justify stopping therapy in men, which is also confirmed by another study . Recently, Kearon et al found that patients with a first unprovoked VTE who had antiphospholipid antibodies still suffer a high risk of subsequent recurrence even after anticoagulant therapy was stopped in response to negative D‐dimer tests .…”

Section: Use Of D‐dimer In Oral Anticoagulation Therapymentioning

confidence: 73%

“…39 This finding revealed that a negative D-dimer level may not be safe enough to justify stopping therapy in men, which is also confirmed by another study. 40 Recently, Kearon et al found that patients with a first unprovoked VTE who had antiphospholipid antibodies still suffer a high risk of subsequent recurrence even after anticoagulant therapy was stopped in response to negative D-dimer tests. 41 All the findings mentioned above indicate that VTE recurrence is associated with multiple factors, and many potential factors are still unsettled, which still need to be clarified in future studies.…”

Section: Use Of D-dimer To Determine the Optimal Duration Of Anticomentioning

confidence: 99%

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Use of D‐dimer in oral anticoagulation therapy

Zhang

Long

Xiao

et al. 2018

Int J Lab Hematology

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Individualized anticoagulation management and improvement of the safety and effectiveness of oral anticoagulant have always been the focus of clinicians' attention. D‐dimer, a sensitive marker of thrombosis and coagulation activation, is not only traditionally used in the diagnosis of venous thromboembolism, acute aortic dissection, and disseminated intravascular coagulation but can also be used as a helpful marker in the management of oral anticoagulant, including evaluating the anticoagulation quality, predicting clinical outcomes, and determining the optimal duration and intensity of anticoagulation.

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Section: Use Of D‐dimer In Oral Anticoagulation Therapymentioning

confidence: 73%

Section: Use Of D-dimer To Determine the Optimal Duration Of Anticomentioning

confidence: 99%

Use of D‐dimer in oral anticoagulation therapy

Zhang

Long

Xiao

et al. 2018

Int J Lab Hematology

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“…D-dimer, small peptide fragments of early thrombosis, is one of the degradation products of fibrin. Prandoni et al 34 reported that D-D detection contributes to monitor the recurrence of venous thromboembolism after systemic anticoagulation therapy for patients. Zhang and his colleagues 35 revealed that D-D level has potential roles in the formation of PVT.…”

Section: Discussionmentioning

confidence: 99%

P-Selectin Level at First and Third Day After Portal Hypertensive Splenectomy for Early Prediction of Portal Vein Thrombosis in Patients With Cirrhosis

Wei

Chen

Shen

et al. 2018

Clin Appl Thromb Hemost

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We aimed to investigate the changes in p-selectin (p-sel), thrombus precursor protein, and D-dimer (D-D) in patients with cirrhosis after portal hypertensive splenectomy and explore its values on the prediction of postoperative portal vein thrombosis (PVT) formation. A total of 144 patients with cirrhosis with portal hypertension who underwent portal hypertensive splenectomy from January 2009 to December 2016 were enrolled in this study and divided into the thrombus and nonthrombus groups. The levels of p-sel, thrombus precursor protein (TpP), and D-D were measured by flow cytometry, enzyme-linked immunosorbent assay, and immunoturbidimetry, respectively. Sensitivity, specificity, and other values for p-sel, TpP, and D-D were calculated. The linear discriminant, logistic regression, and decision tree methods were used to analyze the p-sel value on the prediction of PVT formation. Seventy-nine patients were confirmed having postoperative PVT, with the incidence rate of 54.86%. No significant differences were observed in the p-sel, TpP, and D-D between the thrombus and nonthrombus groups before surgery, but these 3 indexes were obviously elevated in the thrombus group after operation ( P < .01). P-selectin level on first day showed the highest positive predictive value (91.0%) and diagnostic coincidence rate (83.3%), while negative expected value (76.6%) was lower than those of TpP and D-D. Multiple analyses showed the prediction accuracy of PVT was 61.1% ( P = .023), 97.2% ( P < .001), and 97.2% ( P < .001), respectively. P-selectin has a significant value in predicting PVT. P-selectin level on first and third day is valuable and feasible for the early prediction of PVT.

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“…Meanwhile, inflammation is also essential in the occurrence, development as well as prognosis of cerebrovascular diseases and may trigger cerebrovascular events [38] . Secondly, according to the laboratory examination of the severe patients who had coagulation dysfunction and elevated D-dimer [39] , those people may have more possibility of venous thrombosis [40] and hemorrhagic stroke [41] . A 75-year-old woman infected by SARS-CoV-2 without any predisposing factors suffered from severe bilateral pneumonia and acute pulmonary embolism, suggesting the severe infections is a precipitant factor of acute venous embolism and stroke [42] .…”

Section: Neurological Manifestations Of Covid-19mentioning

confidence: 99%