Residue distribution and risk assessment of two macrocyclic lactone insecticides in green onion using micro-liquid-liquid extraction (MLLE) technique coupled with liquid chromatography tandem mass spectrometry

Malhat, Farag; Abdallah, Osama I.

doi:10.1007/s10661-019-7752-1

Cited by 20 publications

(16 citation statements)

References 37 publications

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“…Study of residue behaviour of spinetoram in cauliflower has shown that spinetoram swiftly degraded, with the half-life of 4.85 days (Lin et al 2020). After the application of spinosyne insecticides in green onion in the recommended rates, half-lives for spinetoram was 1.2 days and for spinosad 1.42 days (Malhat & Abdallah 2019). Using results obtained in the dissipation studies, PHI de-termined in tomato was 10 days (Malhat 2013;Hafez et al 2016), while in pepper and cabbage in is only one day (Ali et al 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Spinetoram is a novel semi-syntetic insecticide, a multicomponent tetracyclic macrolide, from the chemical group of spinosyns. It is a chemically modified product of the soil actinomycete Saccharopolyspora spinosa (Mertz & Yao 1990), contained of two closely related components, XDE-175-J and XDE-175-L (Figure 1) (Yamada 2008), present at a ratio of approximately 3 : 1 (Malhat & Abdallah 2019). Although not fully studied, it is known that spinosyns act as allosteric modulators of nicotine acetylcholine receptors (nAChR) (IRAC 2020).…”

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confidence: 99%

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Residue and dissipation dynamic of spinetoram insecticide in pear fruits

Šunjka¹,

Lazić²,

Vuković³

et al. 2021

Plant Prot. Sci.

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Cacopsylla pyri (Linnaeus, 1758) is the most significant and widespread pear pest. It attacks the pear only, causing direct and indirect damages. This study was conducted in order to evaluate the efficacy of insecticide spinetoram in the control of C. pyri. The experiment was set up according to EPPO methods, at the locality Kula (Republic of Serbia) in a pear orchard (Williams variety). Spinetoram (250 g/kg a.i., WG) was foliar applied in the amount of 0.3 kg/ha, during overlapping pest generations, when pear was on BBCH 75 scale. The efficacy was evaluated through the number of larvae aged L1–L3 and L4–L5. Spinetoram has shown satisfying efficacy, especially in the control of L1–L3 larvae (81.6%). In a dissipation study, spinetoram residues in pear fruits were determined using QuEChERS method followed by HPLC-DAD. The method was validated to fulfill SANTE/12682/2019 criteria. Three days after the application, spinetoram residues in pear fruits were below the MRL (0.2 mg/kg). The results have shown that spinetoram dissipation pattern followed the first-order kinetics (R2 = 0.979) with a half-life of 2.17 days, in pear fruits. This study suggests that spinetoram could be safely used in pear, and it could take an important place in insecticide resistance management.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Residue and dissipation dynamic of spinetoram insecticide in pear fruits

Šunjka¹,

Lazić²,

Vuković³

et al. 2021

Plant Prot. Sci.

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“…All samples were SPI-and Et-SPI-negative based on LC-MS/MS. 18,39,40 Rice and green tea were ground and passed through a 60-mesh sieve, and the onions were mashed into mud. All samples were extracted with methanol at a ratio of 1 : 4 (g mL À1 ) under constant shaking for 5 min and centrifuged at 6000 rpm for 3 min.…”

Section: Sample Analysismentioning

confidence: 99%

“…SPI residue data were rst evaluated by the FAO/WHO Joint Meeting of Pesticide Residues in 2001, and the maximum residue limits (MRLs) for SPI and Et-SPI were subsequently established in the European Union (EU) and some countries to protect consumers. 18,19 The US Environmental Protection Agency has set the MRL of SPI at 0.02-4 mg kg À1 in 2016. Onion and tea have SPI MRLs of 0.1 mg kg À1 and 2 mg kg À1 , respectively.…”

Section: Introductionmentioning

confidence: 99%

“…Chromatography-based techniques, including liquid chromatography tandem mass spectrometry and high-performance liquid chromatography, have been used in the analysis of SPI and Et-SPI. 10,19,23 While these methods are sensitive and accurate, they are time consuming, costly, and require complex operating procedures. In recent years, immunoassays have attracted considerable attention due to their high sensitivity, efficiency, and low cost.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative and rapid detection of spinosad and spinetoram by a gold nanoparticle-based immunostrip

Lei

Wang

et al. 2022

Anal. Methods

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Dissipation and dietary exposure risk assessment of spinosad, thiocyclam, and its metabolite nereistoxin in cucumber and groundwater for different population groups

Lin

Wen

et al. 2023

Biomedical Chromatography

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A QuEChERS (quick, easy, cheap, effective, rugged, and safe) technique using ultrahigh‐performance liquid chromatography with tandem mass spectrometry for the analysis of spinosad (spinosyn A + spinosyn D), thiocyclam, and nereistoxin in cucumber was developed with mean recoveries of 93−104%, relative standard deviations of ≤9%, and limits of quantification of 0.01 mg/kg. Field trials of spinosad and thiocyclam were performed in 12 representative cultivating areas in China. Field trial results indicate that spinosyn A and spinosyn D easily dissipated in cucumber with half‐lives of 2.48–6.24 and <3 days, respectively. Nereistoxin was produced after thiocyclam application and was more persistent than its parent. The terminal residues of spinosad were all below the maximum residue limits (0.2 mg/kg) in China, whereas the terminal concentration of nereistoxin (calculated as the stoichiometric equivalent of thiocyclam), which was much higher than that of thiocyclam, was far beyond the maximum residue limits of thiocyclam in cucumber (0.01 mg/kg) established by the European Union. The predicted no‐effect concentrations of spinosyn A, spinosyn D, thiocyclam, and nereistoxin leaching into groundwater were estimated using China‐PEARL (Pesticide Emission Assessment at Regional and Local scales) models after application. However, the dietary (food and water) exposure risk quotient for different populations was below 1 with a preharvest interval set at 5 days after the last application, indicating that the application of spinosad and thiocyclam in cucumber was unlikely to pose unacceptable risk for human health. This study provides data for the safe use of spinosad and thiocyclam in cucumber ecosystem.

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Residue distribution and risk assessment of two macrocyclic lactone insecticides in green onion using micro-liquid-liquid extraction (MLLE) technique coupled with liquid chromatography tandem mass spectrometry

Cited by 20 publications

References 37 publications

Residue and dissipation dynamic of spinetoram insecticide in pear fruits

Residue and dissipation dynamic of spinetoram insecticide in pear fruits

Quantitative and rapid detection of spinosad and spinetoram by a gold nanoparticle-based immunostrip

Dissipation and dietary exposure risk assessment of spinosad, thiocyclam, and its metabolite nereistoxin in cucumber and groundwater for different population groups

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