Residues of grape (Vitis vinifera L.) seed oil production as a valuable source of phenolic antioxidants

Maier, Thorsten J.; Schieber, Andreas; Kammerer, Dietmar R.; Carle, Reinhold

doi:10.1016/j.foodchem.2008.06.005

Cited by 322 publications

(242 citation statements)

References 26 publications

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“…Similarly, Shin and Moon (2010) indicated that GSE has antioxidant properties due to the presence of flavonoids, polyphenols, anthocyanin, pro-anthocyanidins, procyonidins and resveratrol. Several studies suggested that GSE has the ability to increase intracellular vitamin C level (free radical scavenge) and decrease capillary permeability and scavenge oxidant and free radicals (Li et al, 2001;Maier et al, 2009). There was another mechanism of GSE via the induction of endogenous antioxidant enzymes.…”

Section: Ultrastructure Observationsmentioning

confidence: 99%

Effect of Grape Seed Extract, Gervital, Against Methotrexate Induced Histological and Ultrastructural Alterations in Testes of Albino Rats

Arisha¹

2017

WJPR

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The present study was designed to investigate the effect of Gervital on testicular damage induced by the anticancer drug, methotrexate (MXT), in adult male albino rats. Forty male albino rats (Rattus norvegicus) were divided into five experimental groups (8 animals in each one) Group 1: served as control group. Group 2: animals of this group were orally administered grape seed extract only at a dose level of 150mg/kg body weight daily for 28 days. Group 3: animals of this group were intraperitoneally injected with a single dose of MXT (8mg/kg body weight) per week for 4 weeks. Group 4: animals of this group were intraperitoneally injected with a single dose of MXT followed by grape seed extract (GSE) daily for 28 days. Group 5: animals of this group were pretreated with GSE followed by MXT. At the end of the experimental period, all rats were sacrificed. Blood samples were collected for the biochemical study and testes were removed and prepared for histological and ultrastructural studies. Results: Methotrexate significantly reduced the final body and testes weight. Histological observations: several pathological changes were observed in the testicular tissues. These changes include degenerated seminiferous tubules, distorted spermatogenic cells and degenerated interstitial tissue with hemorrhage.Ultrastructural examination showed various severe degenerated features after MXT treatment including types A&B spermatogonia, round and elongated spermatids. On the other hand, GSE administration showed advanced degree of improvement in all the histopathological and ultrastructural changes; the testicular tissues appeared mostly normal.Biochemical analysis revealed that MXT injection significantly reduced serum testosterone level and superoxide dismutase (SOD) activity while, it significantly elevated malondialdehyde (MDA) level. Otherwise, administration of gervital restored the previous

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Section: Ultrastructure Observationsmentioning

confidence: 99%

Effect of Grape Seed Extract, Gervital, Against Methotrexate Induced Histological and Ultrastructural Alterations in Testes of Albino Rats

Arisha¹

2017

WJPR

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“…Due to grape seed has a considerable content of phenolic compounds (around 60 to 70% of the total of minority compound), in smaller percentages in other parts of the fruit, such as in peels (28-35%), and lower values are found in the pulp (approximately 10%) (Revilla et al, 1997). Maier et al (2009) and Shi et al (2003) identified some phenolics compounds such as some monomers (gallic acid, catechin, epicatechin and epicatechin-3-D-gallato) and wide variety of procyanidins oligomers in grape seed.…”

Section: Grape Seed: An Agro-industrial Wastementioning

confidence: 99%

Grape seed oil: a potential functional food?

et al. 2015

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“…Tamoxifen is known to have varied biological effects ranging from complete estrogen antagonism to pure estrogen agonism depending upon its concentrations, the sex of animals and target organ 70 . In humans and rats, Tamoxifen is predominantly antiestrogenic with residual estrogenic activities 19 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2016

IJPSR

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Aim: The present study has been undertaken to investigate the therapeutic effect of GSE (Grape seed extracts) against Tamoxifen (TAM), induced hepatotoxicity in rat. Methods: The rats were divided into four groups • Group 1: rats were injected intraperitoneally (i.p.) with saline for seven days.• Group 2: Rats were treated with TAM in a dose of 45 mg/kg b·w/day, i.p., for seven successive days.• Group 3: Rats were administrated orally GSE (100 mg/kg b·w/day) for three weeks. Group 4: rats were injected (i.p.) (45 mg/kg b·w/day) of Tamoxifen for seven days, then treated daily with a single dose of GSE (100 mg/kg b·w/day) for three weeks respectively. Results: GSE reduced necrosis in the TAM-treated rat. And significantly increased (p<0.05) the levels of MDA and PCC, while the level of GSH was significantly (P<0.05) decreased. Treatment with GSE significantly (P<0.05) reduced. Tamoxifen significantly decreased (P<0.05) the level of NO. GSE significantly increases (P<0.05, Table 2) NO level. Flowcytometric analysis in liver cells, significant increases in apoptotic cells treated by TAM and decreases in the group exposed to TAM and treated with GSE. Conclusion: This study suggests that GSE possesses anti-oxidant effects against TAM toxicity.

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Residues of grape (Vitis vinifera L.) seed oil production as a valuable source of phenolic antioxidants

Cited by 322 publications

References 26 publications

Effect of Grape Seed Extract, Gervital, Against Methotrexate Induced Histological and Ultrastructural Alterations in Testes of Albino Rats

Effect of Grape Seed Extract, Gervital, Against Methotrexate Induced Histological and Ultrastructural Alterations in Testes of Albino Rats

Grape seed oil: a potential functional food?

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