Residues of mancozeb, 2-imidazoline, and ethyleneurea in tomato and potato crops after field treatment with mancozeb

Newsome, W Harvey

doi:10.1021/jf60226a048

Cited by 10 publications

(2 citation statements)

References 6 publications

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“…While human exposure is difficult to quantify, exposure to these pesticides is not limited to agricultural workers who apply it but can reach the general population through spills, drifts, and residues on food products [Newsome, 1976;Ames et al, 1993;McGrew et al, 2000]. Fungicidal DTCs have been used, increasingly, for over 50 years and are applied to a broad range of crops; they can persist in soil for 20-75 days, and have been detected on crops up to 3 weeks after application, and even after washing [Newsome, 1976[Newsome, , 1979Brocker and Schlatter, 1979;Patsakos et al, 1992;Meco et al, 1994]. Families of agricultural workers have extensive opportunities for exposure to agrichemicals, making the effects of developmental and combined exposures critically relevant.…”

Section: Discussionmentioning

confidence: 99%

A Fetal Risk Factor for Parkinson’s Disease

Barlow¹,

Richfield

Cory‐Slechta

et al. 2004

Dev Neurosci

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A lack of strong evidence for genetic heritability of idiopathic Parkinson’s disease (PD) has focused attention on environmental toxicants in the disease etiology, particularly agrichemicals. PD is associated with advanced age, but it is unclear whether specific neuronal damage could result from insults during development. This study hypothesized that prenatal exposure to pesticides would disrupt the development of the nigrostriatal dopamine (DA) system and enhance its vulnerability to dopaminergic neurotoxicant exposures later in life. Pregnant C57BL/6J mice were treated on gestational days 10–17 with saline or the pesticides maneb (MB, 1 mg/kg) or paraquat (PQ, 0.3 mg/kg). When offspring were evaluated in adulthood, there were no significant effects of prenatal MB or PQ exposure on locomotor activity. Subsequently, offspring were treated for 8 consecutive days with saline, MB (30 mg/kg), or PQ (5 mg/kg). One week after the last exposure, only males exposed to prenatal MB and adulthood PQ showed significant reductions in locomotor activity (95%) and changes in striatal neurochemistry. Stereological assessment of the substantia nigra pars compacta (SNpc) and ventral tegmental area correspondingly confirmed selective dopaminergic-neuron loss in SNpc. The lack of changes in other exposure groups suggests a specificity to the sequence of exposures as well as gender specificity. These results suggest that prenatal exposure to MB produces selective, permanent alterations of the nigrostriatal dopaminergic system and enhances adult susceptibility to PQ exposure. This study implicates a role for developmental neurotoxicant exposure in the induction of neurodegenerative disorders such as PD.

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Section: Discussionmentioning

confidence: 99%

A Fetal Risk Factor for Parkinson’s Disease

Barlow¹,

Richfield

Cory‐Slechta

et al. 2004

Dev Neurosci

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“…Results from Interference Tests. The interference of ETU and EDA, subproducts of the decomposition of mancozeb (Newsome, 1979;Newsome et al, 1975;Brandsteterova ´et al, 1986), and the formation of sulfide ions during the decomposition procedure were investigated. ETU and EDA were not extracted by hexane from aqueous solutions.…”

Section: Resultsmentioning

confidence: 99%

Improvement in the Determination of Mancozeb Residues by the Carbon Disulfide Evolution Method Using Flow Injection Analysis

Bohrer

Nascimento

Gomes

1998

J. Agric. Food Chem.

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The sample decomposition of the carbon disulfide evolution method for the determination of dithiocarbamate residues was carried out in a closed vial in the presence of hexane. The evolved carbon disulfide was extracted by the organic solvent and injected in a flow system for its quantification as copper complex. The conditions for batch decomposition, flow injection determination, and association of both were investigated with sodium diethyldithiocarbamate as model substance. An one-channel flow system was employed where the carrier stream was the ethanolic ethylenediamine/copper solution. The determination range was of 0. 01-1.26 microg of CS(2), with a relative standard deviation of 0.06% (n = 10), with a sample throughput of 45 samples/h. The association of the batch decomposition with the flow system was carried out with the fungicide mancozeb and was applied to the analysis of its residue in potato, lettuce, cucumber, and green bean crops. The approach allowed the analysis of 11 samples in triplicate in 2 h, with recoveries between 85% and 92% and relative standard deviation about 2%.

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The disposition of pesticides in higher plants

Quistad

Menn

1983

Residue Reviews

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Residues of mancozeb, 2-imidazoline, and ethyleneurea in tomato and potato crops after field treatment with mancozeb

Cited by 10 publications

References 6 publications

A Fetal Risk Factor for Parkinson’s Disease

A Fetal Risk Factor for Parkinson’s Disease

Improvement in the Determination of Mancozeb Residues by the Carbon Disulfide Evolution Method Using Flow Injection Analysis

The disposition of pesticides in higher plants

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