Residues of neonicotinoids in soil, water and people's hair: A case study from three agricultural regions of the Philippines

Bonmatin, Jean‐Marc; Mitchell, Edward A. D.; Glauser, Gaëtan; Lumawig-Heitzman, Elizabeth; Claveria, Florencia; Lexmond, Maarten Bijleveld van; Taira, Kumiko; Sánchez‐Bayo, Francisco

doi:10.1016/j.scitotenv.2020.143822

Cited by 73 publications

(27 citation statements)

References 53 publications

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“…Similarly, our data demonstrated a geographic bias towards North American and European bees. Given that the risk of neonicotinoid exposure in tropical regions is high (Bonmatin et al, 2019(Bonmatin et al, , 2021, and the importance of wild bees for pollination of crops such as chillies and coffee (Jha & Dick, 2010;Landaverde-González et al, 2017), future research should focus on understanding the potential impact of neonicotinoid exposure on non-Apis bees in tropical regions (Jamieson et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Field‐realistic neonicotinoid exposure has sub‐lethal effects on non‐Apis bees: A meta‐analysis

2021

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Neonicotinoid insecticides can have sub‐lethal effects on bees which has led to calls from conservationists for a global ban. In contrast, agrochemical companies argue that neonicotinoids do not harm honeybees at field‐realistic levels. However, the focus on honeybees neglects the potential impact on other bee species. We conducted a meta‐analysis to assess whether field‐realistic neonicotinoid exposure has sub‐lethal effects on non‐Apis bees. We extracted data from 53 papers (212 effects sizes) and found that it largely consisted of two genera: bumblebees (Bombus) and mason bees (Osmia), highlighting a substantial taxonomic knowledge gap. Neonicotinoid exposure negatively affected reproductive output across all bees and impaired bumblebee colony growth and foraging. Neonicotinoids also reduced Bombus, but not Osmia, individual development (growth and body size). Our results suggest that restrictions on neonicotinoids should benefit bee populations and highlight that the current regulatory process does not safeguard pollinators from the unwanted consequences of insecticide use.

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Section: Discussionmentioning

confidence: 99%

Field‐realistic neonicotinoid exposure has sub‐lethal effects on non‐Apis bees: A meta‐analysis

2021

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“…Data on NN distribution and metabolism in humans are scarce [ 24 ]. There are very few studies in children: six publications on NN urinary levels [ 19 , 25 – 29 ] and one study on NN hair concentrations (6–83 years old people, of whom 28 were < 16 years) [ 30 ]. In China, NN residues in urine were found in 81% of 289 seven to 11 year old school children [ 29 ] and in 100% of 324 tested donors of all ages (1–97 years, 111 children < 18 years) [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Multiple neonicotinoids in children’s cerebro-spinal fluid, plasma, and urine

et al. 2022

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Background Neonicotinoids (NN) are selective neurotoxic pesticides that bind to insect but also mammal nicotinic acetycholine receptors (nAChRs). As the most widely used class of insecticides worldwide, they are ubiquitously found in the environment, wildlife, and foods, and thus of special concern for their impacts on the environment and human health. nAChRs are vital to proper brain organization during the prenatal period and play important roles in various motor, emotional, and cognitive functions. Little is known on children’s contamination by NN. In a pilot study we tested the hypothesis that children’s cerebro-spinal fluid (CSF) can be contaminated by NN. Methods NN were analysed in leftover CSF, blood, and urine samples from children treated for leukaemias and lymphomas and undergoing therapeutic lumbar punctions. We monitored all neonicotinoids approved on the global market and some of their most common metabolites by ultra-high performance liquid chromatography-tandem mass spectrometry. Results From August to December 2020, 14 children were consecutively included in the study. Median age was 8 years (range 3–18). All CSF and plasma samples were positive for at least one NN. Nine (64%) CSF samples and 13 (93%) plasma samples contained more than one NN. Thirteen (93%) CSF samples had N-desmethyl-acetamiprid (median concentration 0.0123, range 0.0024–0.1068 ng/mL), the major metabolite of acetamiprid. All but one urine samples were positive for ≥ one NN. A statistically significant linear relationship was found between plasma/urine and CSF N-desmethyl-acetamiprid concentrations. Conclusions We have developed a reliable analytical method that revealed multiple NN and/or their metabolites in children’s CSF, plasma, and urine. Our data suggest that contamination by multiple NN is not only an environmental hazard for non-target insects such as bees but also potentially for children.

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“…Organisms are likely to be exposed to TMX in the environment. For example, Bonmatin et al 12 analyzed the levels of TMX in soil, water, and human hair sampled from three agricultural regions of the Philippines; they found that TMX levels reached 0.2 ng/L in water, 268 μg/kg in soil, and 0.51 ng/g in hair samples. In another study, TMX was detected in the surface water of the central Yangtze River, China at 1.10 ng/L 13 .…”

Section: Introductionmentioning

confidence: 99%

Thiamethoxam‐induced oxidative stress, lipid peroxidation, and disturbance of steroidogenic genes in male rats: Palliative role of Saussurea lappa and Silybum marianum

Habotta

Ateya

Saleh

et al. 2021

Environmental Toxicology

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Thiamethoxam (TMX) belongs to the neonicotinoid insecticide family and may evoke marked endocrine disruption. In this study, the reproductive toxicity of TMX on male rats was assessed along with the ability of Saussurea lappa (costus roots) and/or Silybum marianum extract (SM) to alleviate TMX toxicity. Male rats were allocated to seven groups and orally treated daily for 4 weeks: Control (saline), Costus (200 mg/kg), SM (150 mg/kg), TMX (78.15 mg/kg), TMX‐costus, TMX‐SM, and TMX‐costus‐SM (at the aforementioned doses). Compared with control group, TMX administration induced reductions in testicular levels of glutathione and antioxidant activities of SOD and CAT. In addition, TMX‐exposed rats showed lower serum testosterone hormonal levels as well as higher malondialdehyde and nitric acid levels were detected in TMX‐administered rats. On a molecular basis, mRNA expressions of StAR, CYP17a, 3β‐HSD, SR‐B1, and P450scc genes were significantly down‐regulated in TMX group, whereas the expression of LHR and aromatase genes was up‐regulated. Moreover, TMX‐induced testicular damage was confirmed by histopathological screening. Importantly, however, the administration of either costus roots or SM significantly alleviated all aforementioned TMX‐induced changes, indicating the effective antioxidant activities of these plant products. Interestingly, simultaneous treatment with costus root and SM provided better protection against TMX reproduction toxicity than treatment with either agent alone.

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Residues of neonicotinoids in soil, water and people's hair: A case study from three agricultural regions of the Philippines

Cited by 73 publications

References 53 publications

Field‐realistic neonicotinoid exposure has sub‐lethal effects on non‐Apis bees: A meta‐analysis

Field‐realistic neonicotinoid exposure has sub‐lethal effects on non‐Apis bees: A meta‐analysis

Multiple neonicotinoids in children’s cerebro-spinal fluid, plasma, and urine

Thiamethoxam‐induced oxidative stress, lipid peroxidation, and disturbance of steroidogenic genes in male rats: Palliative role of Saussurea lappa and Silybum marianum

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