Discussing the linkages between local entrepreneurship and tourism development in peripheral areas provides an intriguing starting point for a wider reflection on the role of existing policies and of emerging practices in fostering local development in such territories. Peripheral areas are typically considered as areas relatively far from urban hubs providing essential services, normally suffering from de-anthropisation and marginalisation, though often provided with a wide range of environmental, cultural and social resources. For a few decades now, and particularly since 2000s, we have witnessed the publication of a growing number of scientific research and policy reports aimed at fostering, triggering and sustaining an increasingly timely debate on what to do (if anything) with peripheral areas and lagging-behind regions ((2009) tackling persistent underutilization of potential for development in specific places; two OECD reports (2009a; 2009b) dealing with the disparities between regions that entail underutilizes potential for growth; a Word Bank's report (2009) that acknowledges the unbalanced nature of growth in lagging regions. Two approaches to the question of why peripheral areas are unable to pursue and succeed in exiting their condition, and of how to effectively counterbalance this ongoing process, have emerged (Barca, McCann, & Rodríguez-Pose, 2012): one is the invitation to reflect on the so called "spatially-blind" or "people-based" interventions, that see the implementation of policies that have not been designed to take into consideration the spaces and places of implementation; the other refers to "place-based" interventions, that assume that the local contextwidely understoodmatters, and that adequate degrees of citizenship are warranted by an improvement in peoples' lives and equal access to opportunities.Moreover, the place-based approach, emphasizes another central issue, that of knowledge in policy interventions and particularly of the potentialities provided by relying on the embedded local knowledge, in contrast with the space-blind approaches to regional development, which imply that the state has both the knowledge and the capacity to design policy interventions regardless of the specificities of the geographical contexts (Barca et al., 2012).