Resistance and cross-resistance to insecticides in human head lice from Florida and California

Yoon, Kyong Sup; Gao, Jianrong; Lee, Si Hyeock; Coles, G.C.; Meinking, Terri L.; Taplin, David; Edman, John D.; Takano-Lee, Miwako; Clark, J. Marshall

doi:10.1016/j.pestbp.2004.07.008

Cited by 63 publications

(39 citation statements)

References 21 publications

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“…The authors identified two point mutations on the sodium channel in the resistant populations. Yoon et al (2004) detected permethrin resistance in head lice from Florida and California and established DDT cross-resistance. Susceptible populations from Panamá and Ecuador do not posses mutations T9291and L932F while all the resistant populations have both, indicating that in this case permethrin resistance is based on a kdr-type mechanism.…”

Section: Discussionmentioning

confidence: 94%

Activity of increased specific and non-specific esterases and glutathione transferases associated with resistance to permethrin in pediculus humanus capitis (phthiraptera: pediculidae) from Argentina

et al. 2009

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Enhanced metabolism by oxidative enzymes is a major cause of pyrethroid resistance in insects. In this work, we evaluated the role of specific and non-specific esterases in head louse populations from Buenos Aires with different levels of resistance to permethrin. As esterase activity is substrate-dependent, four different esters were used as unspecific substrates in order to obtain a better characterization of the possible role of these enzymes in the resistance phenomenon. The unspecific substrates were phenylthioacetate, 1- and 2-naphtyl-acetate, and p-nitrophenyl acetate. A 7-coumaryl permethrate was synthesized and used as a specific substrate to measure pyrethroid esterases by a very sensitive microfluorometric method. The results on pyrethroid esterase activity obtained with this substrate showed that these enzymes contribute to the detoxifying activity in resistant populations, although no correlation was found between pyrethroid esterase activity and resistance ratios. In this study, we established that the activity of esterase against specific and non-specific substrates is increased in pyrethroid-resistant populations of head lice from Buenos Aires. Also, dichlorodiphenyltrichloroethane (DDT) resistance values demonstrated that there is a DDT cross-resistance phenomenon in pyrethroid-resistant head louse populations and suggested that an alteration in the receptor of the nervous system (kdr gen) is a key factor of the resistance phenomena in these head louse populations.

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Section: Discussionmentioning

confidence: 94%

Activity of increased specific and non-specific esterases and glutathione transferases associated with resistance to permethrin in pediculus humanus capitis (phthiraptera: pediculidae) from Argentina

et al. 2009

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“…As the mode of action appears to be mainly due to the physical effects of coconut oil coating the louse surface, it is not envisaged that lice may develop resistance to the product unlike pharmacologically active insecticides like permethrin. Resistance to permethrin has been shown to cause treatment failure in the UK [10,15]. We would therefore expect to encounter a proportion of cases in every community with lice resistant to permethrin.…”

Section: Discussionmentioning

confidence: 99%

Clinical trial showing superiority of a coconut and anise spray over permethrin 0.43% lotion for head louse infestation, ISRCTN96469780

Burgess¹,

Brunton²,

Burgess³

2009

Eur J Pediatr

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Permethrin is the most widely used pediculicide, but evidence of resistance from several countries and anecdotal reports from Germany suggest that permethrin lotion is now less effective. We designed a randomized, controlled, parallel group trial involving 100 participants with active head louse infestation to investigate the activity of a coconut and anise spray and to see whether permethrin lotion is still effective, using two applications of product 9 days apart. The spray was significantly more successful (41/50, 82.0%) cures compared with permethrin (21/50, 42.0%; p < 0.0001, difference 40.0%, 95% confidence interval of 22.5% to 57.5%). Per-protocol success was 83.3% and 44.7%, respectively. Thirty-three people reported irritant reactions following alcohol contact with excoriated skin. We concluded that, although permethrin lotion is still effective for some people, the coconut and anise spray can be a significantly more effective alternative treatment.

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“…Over the last two decades, resistance to pyrethrins and pyrethroid insecticides by the human head louse, Pediculus humanus capitis, has been widely documented (Burgess et al, 1995;Downs et al, 1999a;Downs et al, 1999b;Chosidow et al, 1994;Mumcuoglu et al, 1995;Hemingway et al, 1999;Rupes et al, 1995;Picollo et al, 1998;Vassena et al, 2003;Yoon et al, 2003;Yoon et al, 2004;Lee et al, 2000b). Heightened public and governmental concerns have occurred because of increased incidents of head louse infestations among school children (http://www.cdc.gov/ncidod/dpd/parasites/lice/default.htm; http://www.headlice.org).…”

Section: Introductionmentioning

confidence: 99%

Three mutations identified in the voltage-sensitive sodium channel α-subunit gene of permethrin-resistant human head lice reduce the permethrin sensitivity of house fly Vssc1 sodium channels expressed in Xenopus oocytes

SupYoon

Symington

Lee

et al. 2008

Insect Biochemistry and Molecular Biology

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Point mutations in the para-orthologous sodium channel α-subunit of the head louse (M815I, T917I and L920F) are associated with permethrin-and DDT-resistance. These mutations were inserted in all combinations using site-directed mutagenesis at the corresponding amino acid sequence positions (M827I, T929I and L932F) of the house fly para-orthologous voltage-sensitive sodium channel α-subunit (Vssc1 WT ) gene and heterologously co-expressed with the sodium channel auxiliary subunit of house fly (Vsscβ) in Xenopus oocytes. The double mutant possessing M827I and T929I (Vssc1 MITI /Vsscβ) caused a ~4.0 mV hyperpolarizing shift and the triple mutant, Vssc1 MITILF / Vsscβ, caused a ~3.2 mV depolarizing shift in the voltage dependence of activation curves. Vssc1 MITI /Vsscβ, Vssc1 TILF /Vsscβ and Vssc1 MITILF /Vsscβ caused depolarizing shifts (~6.6, ~7.6 and ~8.8 mV, respectively) in the voltage dependence of steady-state inactivation curves. The M827I and L932F mutations reduced permethrin sensitivity when expressed alone but the T929I mutation, either alone or in combination, virtually abolished permethrin sensitivity. Thus, the T929I mutation is the principal cause of permethrin resistance in head lice. Comparison of the expression rates of channels containing single, double and triple mutations with that of Vssc1 WT /Vsscβ channels indicates that the M827I mutation may play a role in rescuing the decreased expression of channels containing T929I.

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Resistance and cross-resistance to insecticides in human head lice from Florida and California

Cited by 63 publications

References 21 publications

Activity of increased specific and non-specific esterases and glutathione transferases associated with resistance to permethrin in pediculus humanus capitis (phthiraptera: pediculidae) from Argentina

Activity of increased specific and non-specific esterases and glutathione transferases associated with resistance to permethrin in pediculus humanus capitis (phthiraptera: pediculidae) from Argentina

Clinical trial showing superiority of a coconut and anise spray over permethrin 0.43% lotion for head louse infestation, ISRCTN96469780

Three mutations identified in the voltage-sensitive sodium channel α-subunit gene of permethrin-resistant human head lice reduce the permethrin sensitivity of house fly Vssc1 sodium channels expressed in Xenopus oocytes

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