Resistance and susceptibility to Marek’s disease: nitric oxide synthase/arginase activity balance

Djeraba, Aouatef; Musset, Eugène; Rooijen, Nico van; Quéré, Pascale

doi:10.1016/s0378-1135(02)00010-x

Cited by 23 publications

(10 citation statements)

References 42 publications

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“…Monocyte/macrophage-derived NO may also block replication of DENV, another mosquito-transmitted flavivirus. Infection with DENV resulted in increased levels of NO in patients with dengue fever, the classic form of the disease (37). Additionally, iNOS expression was induced in CD14 + monocytes from a subset of acutely infected individuals (13).…”

Section: No Production Can Be Beneficial During Virus Infectionmentioning

confidence: 99%

The Role of Myeloid Cell Activation and Arginine Metabolism in the Pathogenesis of Virus-Induced Diseases

Burrack

Morrison

2014

Front. Immunol.

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When an antiviral immune response is generated, a balance must be reached between two opposing pathways: the production of proinflammatory and cytotoxic effectors that drive a robust antiviral immune response to control the infection and regulators that function to limit or blunt an excessive immune response to minimize immune-mediated pathology and repair tissue damage. Myeloid cells, including monocytes and macrophages, play an important role in this balance, particularly through the activities of the arginine-hydrolyzing enzymes nitric oxide synthase 2 (Nos2; iNOS) and arginase 1 (Arg1). Nitric oxide (NO) production by iNOS is an important proinflammatory mediator, whereas Arg1-expressing macrophages contribute to the resolution of inflammation and wound repair. In the context of viral infections, expression of these enzymes can result in a variety of outcomes for the host. NO has direct antiviral properties against some viruses, whereas during other virus infections NO can mediate immunopathology and/or inhibit the antiviral immune response to promote chronic infection. Arg1 activity not only has important wound healing functions but can also inhibit the antiviral immune response during some viral infections. Thus, depending on the specific virus and the tissue(s) involved, the activity of both of these arginine-hydrolyzing enzymes can either exacerbate or limit the severity of virus-induced disease. In this review, we will discuss a variety of viral infections, including HIV, SARS-CoV, LCMV, HCV, RSV, and others, where myeloid cells influence the control and clearance of the virus from the host, as well as the severity and resolution of tissue damage, via the activities of iNOS and/or Arg1. Clearly, monocyte/macrophage activation and arginine metabolism will continue to be important areas of investigation in the context of viral infections.

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Section: No Production Can Be Beneficial During Virus Infectionmentioning

confidence: 99%

The Role of Myeloid Cell Activation and Arginine Metabolism in the Pathogenesis of Virus-Induced Diseases

Burrack

Morrison

2014

Front. Immunol.

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“…Norvaline is an amino acid (C 5 H 11 NO 2 ) isomeric with valine, and is commonly made synthetically. It has several significances in biological systems (1)(2)(3)(4)(5)(6)(7)(8)(9). The importance of metal ions to vital functions in living systems and for the well being of living organisms is now well established.…”

Section: Introductionmentioning

confidence: 99%

Studies on biologically important copper(II) / manganese(II) / uranyl(II) – norvaline binary complexes

Tewari

2008

Maced. J. Chem. Chem. Eng.

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In coordination compounds studies, a knowledge of the magnitude of the stability constants of complexes is necessary for preliminary quantitative treatment. Described herein is a method that involves the use of advanced ionophoretic technique for the study of the equilibria in binary complex systems in solution. This method is based upon the migration of a spot of the metal ion on a paper strip at different pH values of background electrolyte containing 0.1 M perchloric acid and 0.01 M norvaline. A graph of pH against mobility provides information about the nature of the complexation and helps in calculating stability constants. Using this method, the stability constants of binary complexes metal(II) – norvaline have been determined to be (8.11 ± 0.02, 7.03 ± 0.09); (3.77 ± 0.11, 2.39 ± 0.07) and (7.59 ± 0.05, 6.17 ± 0.04) (log K values) for Cu(II), Mn(II) and UO2(II) complexes, respectively, at 35 ºC.

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“…NO production in macrophages of intestine is one of the ways of non specific defense at gut mucosa. It has now been fully established that NO in macrophages is associated with many of the antiviral, tumoricidal (Djeraba et al, 2002). and anti-protozoal activity (Weisz et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

Intestinal nitric oxide synthase (NOS) in broiler chick: Cloning, sequencing and homology analysis

Bera¹,

Pan²,

Manna

et al. 2009

Proc Zool Soc

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An attempt has been made for molecular characterization of gut mucosal nitric oxide synthase (NOS) in broiler chicks. Since, NO is a bioregulatory effector molecule of innate immunity and gut mucosal resistance in chicks mainly relies on this immunity hence, small intestine and caecum were used for the study. The study revealed that mRNA was expressed in all the group at 7 th , 14 th and 21 st days. The amplified products of 371 bp were cloned and sequenced for confirmation. Subsequent homology analysis revealed that mRNA sequence of intestinal NOS of Gallus gallus (EF178279) was 100 % similar with NOS of chicken hepatocytes (NM_204961). It differed 0.29 %, 3.20% and 4.08% with NOS of chicken ventricular myocytes (D85422), Coturnix coturnix (DQ206459) and Numida meleagridis (EU000565) respectively. These variations were mainly due to transversion. The information on the biological marker in avian mucosal system is of great importance for its role in antimicrobial activities in early enteric infection by various pathogens.

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Resistance and susceptibility to Marek’s disease: nitric oxide synthase/arginase activity balance

Cited by 23 publications

References 42 publications

The Role of Myeloid Cell Activation and Arginine Metabolism in the Pathogenesis of Virus-Induced Diseases

The Role of Myeloid Cell Activation and Arginine Metabolism in the Pathogenesis of Virus-Induced Diseases

Studies on biologically important copper(II) / manganese(II) / uranyl(II) – norvaline binary complexes

Intestinal nitric oxide synthase (NOS) in broiler chick: Cloning, sequencing and homology analysis

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