Resistance in Enteric Shigella and nontyphoidal Salmonella: emerging concepts

Yang, Chaojie; Xiang, Ying; Qiu, Shaofu

doi:10.1097/qco.0000000000000960

Cited by 10 publications

(2 citation statements)

References 64 publications

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“…Due to the growing prevalence of resistance to ciprofloxacin and ceftriaxone, azithromycin is considered a final option, United States Food and Drug Administration (FDA)-approved antimicrobial agents, particularly for managing systemic infections, including those attributable to Shigella spp [ 7 ]. The current study is designed to utilize a range of computational tools and techniques to identify a potential drug target for combating infectious diseases caused by S .…”

Section: Introductionmentioning

confidence: 99%

An integrated in-silico approach for drug target identification in human pathogen Shigella dysenteriae

Qureshi,

Basheer,

Sajjad

et al. 2024

PLoS ONE

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Shigella dysenteriae, is a Gram-negative bacterium that emerged as the second most significant cause of bacillary dysentery. Antibiotic treatment is vital in lowering Shigella infection rates, yet the growing global resistance to broad-spectrum antibiotics poses a significant challenge. The persistent multidrug resistance of S. dysenteriae complicates its management and control. Hence, there is an urgent requirement to discover novel therapeutic targets and potent medications to prevent and treat this disease. Therefore, the integration of bioinformatics methods such as subtractive and comparative analysis provides a pathway to compute the pan-genome of S. dysenteriae. In our study, we analysed a dataset comprising 27 whole genomes. The S. dysenteriae strain SD197 was used as the reference for determining the core genome. Initially, our focus was directed towards the identification of the proteome of the core genome. Moreover, several filters were applied to the core genome, including assessments for non-host homology, protein essentiality, and virulence, in order to prioritize potential drug targets. Among these targets were Integration host factor subunit alpha and Tyrosine recombinase XerC. Furthermore, four drug-like compounds showing potential inhibitory effects against both target proteins were identified. Subsequently, molecular docking analysis was conducted involving these targets and the compounds. This initial study provides the list of novel targets against S. dysenteriae. Conclusively, future in vitro investigations could validate our in-silico findings and uncover potential therapeutic drugs for combating bacillary dysentery infection.

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Section: Introductionmentioning

confidence: 99%

An integrated in-silico approach for drug target identification in human pathogen Shigella dysenteriae

Qureshi,

Basheer,

Sajjad

et al. 2024

PLoS ONE

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“…secondary to drug overuse in human medicine and in the food industry remains one of the biggest problems in global health [9,10]. Multidrugresistant outbreaks have recently been reported in high-income countries, as well [11].…”

Section: Introductionmentioning

confidence: 99%

Molecular Signature of Monocytes Shaped by the Shigella sonnei 1790-Generalized Modules for Membrane Antigens Vaccine

Tondi,

Siena,

Essaghir

et al. 2024

IJMS

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Shigellosis, an acute gastroenteritis infection caused by Shigella species, remains a public health burden in developing countries. Recently, many outbreaks due to Shigella sonnei multidrug-resistant strains have been reported in high-income countries, and the lack of an effective vaccine represents a major hurdle to counteract this bacterial pathogen. Vaccine candidates against Shigella sonnei are under clinical development, including a Generalized Modules for Membrane Antigens (GMMA)-based vaccine. The mechanisms by which GMMA-based vaccines interact and activate human immune cells remain elusive. Our previous study provided the first evidence that both adaptive and innate immune cells are targeted and functionally shaped by the GMMA-based vaccine. Here, flow cytometry and confocal microscopy analysis allowed us to identify monocytes as the main target population interacting with the S. sonnei 1790-GMMA vaccine on human peripheral blood. In addition, transcriptomic analysis of this cell population revealed a molecular signature induced by 1790-GMMA mostly correlated with the inflammatory response and cytokine-induced processes. This also impacts the expression of genes associated with macrophages’ differentiation and T cell regulation, suggesting a dual function for this vaccine platform both as an antigen carrier and as a regulator of immune cell activation and differentiation.

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Alarming increase in fluoroquinolone resistance among non-typhoidal salmonella isolates

Beşli,

Keske,

Dikenelli

et al. 2024

Clinical Microbiology and Infection

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Resistance in Enteric Shigella and nontyphoidal Salmonella: emerging concepts

Cited by 10 publications

References 64 publications

An integrated in-silico approach for drug target identification in human pathogen Shigella dysenteriae

An integrated in-silico approach for drug target identification in human pathogen Shigella dysenteriae

Molecular Signature of Monocytes Shaped by the Shigella sonnei 1790-Generalized Modules for Membrane Antigens Vaccine

Alarming increase in fluoroquinolone resistance among non-typhoidal salmonella isolates

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