Resistance of four sheep breeds to natural and subsequent artificial Haemonchus contortus infection

Mugambi, JM; Bain, R.K.; Wanyangu, S.W.; Ihiga, M. A. K.; Duncan, J.L.; Murray, M.; Stear, M. J.

doi:10.1016/s0304-4017(96)01128-4

Cited by 67 publications

(30 citation statements)

References 9 publications

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“…However, surprisingly no significant differences were established following an artificial challenge with the same nematode species. On the contrary, a different study [30] fully confirmed the results of Mugambi et al [22] in a comparison of the Red Maasai and the Dorper breed. Wanyangu et al [30] [16].…”

Section: Between Breed Variationsupporting

confidence: 54%

“…In a comparison of four breeds, the Red Maasai breed showed higher resistance to H. contortus than Blackheaded Somali and Dorper sheep [22] and all three breeds were substantially more resistant than the Romney Marsh breed. A study by Baker et al [2] found significantly different FEC between Dorper and Red Maasai sheep with the Red Maasai breed showing lower FEC following a field infection with H. contortus.…”

Section: Between Breed Variationmentioning

confidence: 90%

“…Several studies [2,16,22,23,30] have compared different breeds for their ability to resist internal nematode infections and as a result variation between breeds has been observed. In a comparison of four breeds, the Red Maasai breed showed higher resistance to H. contortus than Blackheaded Somali and Dorper sheep [22] and all three breeds were substantially more resistant than the Romney Marsh breed.…”

Section: Between Breed Variationmentioning

confidence: 99%

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Quantitative trait loci for internal nematode resistance in sheep: a review

Dominik¹

2005

Genet. Sel. Evol.

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-Internal nematode resistance in sheep has a large impact on the economy of sheep industries. Selection for nematode resistance in sheep breeding schemes would help to reduce the direct and indirect cost of parasitism to these industries. However, this is not widely practiced because of the difficulty of measuring parasite resistance or correlated indirect selection criteria. The identification of genes or linked markers that have a significant association with the variance of indicator traits of internal nematode resistance in sheep would facilitate the inclusion of nematode resistance in sheep breeding operations. This review summarises findings reported in the literature of quantitative trait loci for internal nematode resistance in sheep. Issues relating to the analytical and phenotypic complexity of nematode resistance are discussed in the context of the findings of quantitative trait loci for nematode resistance published to date.sheep / internal nematode resistance / quantitative trait loci

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Section: Between Breed Variationsupporting

confidence: 54%

Section: Between Breed Variationmentioning

confidence: 90%

Section: Between Breed Variationmentioning

confidence: 99%

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Quantitative trait loci for internal nematode resistance in sheep: a review

Dominik¹

2005

Genet. Sel. Evol.

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“…Indeed, IgA levels and faecal egg counts (FEC) have been used as selectable markers for resistance [8,15,16]. Furthermore, different sheep breeds show marked diversity in resistance to helminth infection [17-19]. Consequently, one strategy for the non-pharmacological control of parasites is the exploitation of genetic variation for resistance found within and between different sheep breeds [20,21].…”

Section: Introductionmentioning

confidence: 99%

Exploring the abomasal lymph node transcriptome for genes associated with resistance to the sheep nematode Teladorsagia circumcincta

Gossner

Wilkie

Joshi

2013

Vet Res

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This study exploited Blackface lambs that varied in their resistance to the abomasal nematode parasite, Teladorsagia circumcincta. Infection of these lambs over 3 months identified susceptible (high adult worm count, high faecal egg count and low IgA antibody) and resistant animals that had excluded all parasites. Previous work had shown that susceptibility and resistance is dependent on the differential immune response to the parasite, which occurs within the abomasal (gastric) lymph node (ALN) that drains the site of infection. The Affymetrix ovine gene array was used to interrogate the transcriptome of the ALN to identify genes and physiological pathways associated with resistance. We used a bovine RT-qPCR array of 84 genes to validate the gene array, and also report digital gene expression analysis on the same tissues, reanalysed using the Oar v3.1 sheep genome assembly. These analyses identified Humoral Immune Response, Protein Synthesis, Inflammatory Response and Hematological System Development and Function as the two top-ranked networks associated with resistance. Central genes within these networks were IL4, IL5, IL13RA2 and in particular IL13, which confirmed that differential activation of Th2 polarized responses is critical to the resistance phenotype. Furthermore, in resistant sheep there was up-regulation of genes linked to control and suppression of inflammation. The identity of differentially-expressed chemokines and receptors in the resistant and susceptible sheep also begins to explain the cellular nature of the host response to infection. This work will greatly help in the identification of candidate genes as potential selectable markers of genetic resistance.

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“…In spite of the strong correlation between FAMACHA © score and fluke burden in the present study, these variables each correlated only moderately with PCV. It is likely that unrecorded factors such as age, sex, breed and physiological status contributed to high variability in PCV in the present study, since these factors are known to affect PCV (Mugambi et al, 1997;Vanimisetti et al, 2004). Collection of blood from the severed jugular veins rather than intravenously could also have increased variation in estimated PCV.…”

Section: Discussionmentioning

confidence: 75%

Olah

Wyk

Wall

et al. 2015

Veterinary Parasitology

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