RESISTANCE OF MECHANICAL AND ELECTRICAL RESPONSES TO HYPOGASTRIC NERVE STIMULATION TO Α-Blocking AGENTS IN GUINEA-PIG VAS DEFERENS

Nakanishi, Hironori; Doteuchi, Masami; Takeda, Hiroshi

doi:10.1254/jjp.20.61

Japanese Journal of Pharmacology

1970

DOI: 10.1254/jjp.20.61

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RESISTANCE OF MECHANICAL AND ELECTRICAL RESPONSES TO HYPOGASTRIC NERVE STIMULATION TO Α-Blocking AGENTS IN GUINEA-PIG VAS DEFERENS

Hironori Nakanishi

Masami Doteuchi

Hiroshi Takeda

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Cited by 4 publications

(1 citation statement)

References 15 publications

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“…Accepted for publication November 30, 1970. this conclusion is generally not questioned. Indeed it has been substantiated in recent studies with both vascular (5) and nonvascular tissues (6,7).…”

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Distribution Theory of Resistance of Neurogenic Vasoconstriction to Alpha-Receptor Blockade in the Rabbit

Bevan

1971

Circulation Research

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The effects of a-receptor-blocking agents on the contractile responses of isolated rabbit arteries to sympathetic nerve stimulation and exogenous lnorepinephrine (Z-NE) were compared. In the pulmonary artery and aorta, yohimbine, phentolamine, and phenoxybenzamine blocked the response to nerve stimulation less than that to an equipotent dose of Z-NE. This resistance of neurogenic response was independent of the frequency and number of stimuli and persisted after inhibition of the nerve Z-NE uptake by cocaine. The neurogenically released transmitter Z-NE probably forms a high concentration near the adventitia-media junction, whereas the exogenous NE is distributed evenly throughout the thickness of media. Thus higher concentrations of a-receptor-blocking agents would be needed to block the effect of neurogenic Z-NE than to block that of exogenous Z-NE. This explanation of the resistance was thought to be more appropriate to the large vessels tested than that based on neuroeffector proximity. KEY WORDSdistribution of NE phentolamine tunica media neuroeffector distance yohimbine smooth muscle phenoxybenzamine cocaine • In 1906, Dale (1) observed that ergot was less effective in blocking the effector response to sympathetic nervous activity than that to circulating epinephrine. Subsequently, parallel observations have been made with various areceptor blocking agents at many adrenergically innervated sites. In his review, Nickerson (2) concluded that all a-receptor-blocking agents appear to be more effective against responses to circulating sympathomimetic agents than against responses to sympathetic nervous activity. All degrees of relative effectiveness of a-receptor-blocking agents against these two types of responses may be found at different sites in the body. With the exception of Levin and Beck (3) and Urquilla et al. (4),

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confidence: 76%

Distribution Theory of Resistance of Neurogenic Vasoconstriction to Alpha-Receptor Blockade in the Rabbit

Bevan

1971

Circulation Research

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The Possible Role of Adenosine Triphosphate in Chemical Transmission Between the Hypogastric Nerve Terminal and Seminal Vesicle in the Guinea-Pig

Nakanishi

TAKEDA

1973

Japanese Journal of Pharmacology

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The Possibility that Adenosine Triphosphate is an Excitatory Transmitter in Guinea-Pig Seminal Vesicle

Nakanishi¹,

TAKEDA²

1972

Japanese Journal of Pharmacology

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RESISTANCE OF MECHANICAL AND ELECTRICAL RESPONSES TO HYPOGASTRIC NERVE STIMULATION TO Α-Blocking AGENTS IN GUINEA-PIG VAS DEFERENS

Cited by 4 publications

References 15 publications

Distribution Theory of Resistance of Neurogenic Vasoconstriction to Alpha-Receptor Blockade in the Rabbit

Distribution Theory of Resistance of Neurogenic Vasoconstriction to Alpha-Receptor Blockade in the Rabbit

The Possible Role of Adenosine Triphosphate in Chemical Transmission Between the Hypogastric Nerve Terminal and Seminal Vesicle in the Guinea-Pig

The Possibility that Adenosine Triphosphate is an Excitatory Transmitter in Guinea-Pig Seminal Vesicle

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