Resistance of mice lacking the serum- and glucocorticoid-inducible kinase SGK1 against salt-sensitive hypertension induced by a high-fat diet

Huang, Dan; Boini, Krishna M.; Oßwald, Hartmut; Friedrich, Björn; Artunc, Ferruh; Ullrich, Susanne; Rajamanickam, Jeyaganesh; Palmada, Mònica; Wulff, Peer; Kuhl, Dietmar; Vallon, Volker; Läng, Florian

doi:10.1152/ajprenal.00299.2005

Cited by 66 publications

(57 citation statements)

References 81 publications

(101 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Importantly, fluid intake, urinary flow rate, and urinary sodium chloride excretion was significantly increased in sgk1(Ϫ/Ϫ) mice, and blood pressure was elevated in wild-type but not sgk1(Ϫ/Ϫ) mice (70). These experiments demonstrate an important role of Sgk1 in the hypertensive effects of a combined high-fat/high-salt diet, probably by the combined action in glomeruli, distal tubules, and proximal tubular cells.…”

Section: Potential Role Of Impaired Corticosteroid Regulation In Westmentioning

confidence: 68%

“…It has been shown that a high-fat/high-salt diet stimulated renal Sgk1 expression in mice (70). Importantly, fluid intake, urinary flow rate, and urinary sodium chloride excretion was significantly increased in sgk1(Ϫ/Ϫ) mice, and blood pressure was elevated in wild-type but not sgk1(Ϫ/Ϫ) mice (70).…”

Section: Potential Role Of Impaired Corticosteroid Regulation In Westmentioning

confidence: 99%

See 1 more Smart Citation

The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease

Odermatt

2011

American Journal of Physiology-Renal Physiology

217

128

View full text Add to dashboard Cite

The Western-style diet is characterized by its highly processed and refined foods and high contents of sugars, salt, and fat and protein from red meat. It has been recognized as the major contributor to metabolic disturbances and the development of obesity-related diseases including type 2 diabetes, hypertension, and cardiovascular disease. Also, the Western-style diet has been associated with an increased incidence of chronic kidney disease (CKD). A combination of dietary factors contributes to the impairment of renal vascularization, steatosis and inflammation, hypertension, and impaired renal hormonal regulation. This review addresses recent progress in the understanding of the association of the Western-style diet with the induction of dyslipidemia, oxidative stress, inflammation, and disturbances of corticosteroid regulation in the development of CKD. Future research needs to distinguish between acute and chronic effects of diets with high contents of sugars, salt, and fat and protein from red meat, and to uncover the contribution of each component. Improved therapeutic interventions should consider potentially altered drug metabolism and pharmacokinetics and be combined with lifestyle changes. A clinical assessment of the long-term risks of whole-body disturbances is strongly recommended to reduce metabolic complications and cardiovascular risk in kidney donors and patients with CKD.

show abstract

Section: Potential Role Of Impaired Corticosteroid Regulation In Westmentioning

confidence: 68%

Section: Potential Role Of Impaired Corticosteroid Regulation In Westmentioning

confidence: 99%

The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease

Odermatt

2011

American Journal of Physiology-Renal Physiology

217

128

View full text Add to dashboard Cite

show abstract

“…For instance, insulin has been shown to modulate the blood pressure response to aldosterone (30), and decrease in plasma aldosterone could contribute to the change of blood pressure with weight loss and resulting plasma insulin reduction (31). Also, in studies conducted in hyperinsulinemic rodents, a lack of aldosterone suppression by salt has been demonstrated (32). Relevant to this issue, it should be noticed that, in our study, systolic blood pressure had a weaker relationship with plasma aldosterone than diastolic blood pressure, as a likely result of its greater intrinsic variability.…”

Section: Discussionmentioning

confidence: 99%

Insulin Resistance and Hyperinsulinemia Are Related to Plasma Aldosterone Levels in Hypertensive Patients

et al. 2007

View full text Add to dashboard Cite

OBJECTIVE -An association between aldosterone and insulin resistance has been demonstrated in obesity and primary aldosteronism and in blacks with the metabolic syndrome. The aim of this study was to evaluate the relationship of plasma aldosterone with insulin sensitivity in white subjects. RESEARCH DESIGN AND METHODS -In 356 patients with essential hypertensionand 102 normotensive control subjects of comparable age and BMI, we measured, after discontinuation of treatment, plasma active renin, aldosterone, cortisol, glucose, insulin, and C-peptide levels and calculated markers of insulin sensitivity. Direct assessment of insulin sensitivity was obtained in a subset of 64 hypertensive patients by a hyperinsulinemic clamp.RESULTS -Hypertensive patients had significantly greater fasting plasma insulin and Cpeptide concentrations and homeostasis model assessment (HOMA) indexes than normotensive control subjects. A positive association with increasing plasma aldosterone concentrations was demonstrated for plasma glucose, insulin, C-peptides, and HOMA. Assessment of insulin sensitivity by clamp showed a significant decrease of the metabolic clearance rate of glucose with increasing aldosterone levels. Significant correlations were found between plasma aldosterone, plasma insulin, and C-peptide levels, HOMA, and glucose metabolic clearance rate. Blood pressure and plasma potassium, plasma cortisol, and renin levels, but not BMI, were also directly correlated with plasma aldosterone. Multiple regression analysis showed that HOMA, together with plasma potassium, cortisol, and renin levels, was independently correlated with plasma aldosterone.CONCLUSIONS -This study demonstrates a direct relationship between aldosterone, insulin resistance, and hyperinsulinemia in white subjects. In patients with hypertension, this relationship might contribute to maintenance of high blood pressure and increased cardiovascular risk. Diabetes Care 30:2349-2354, 2007S eminal studies that were published Ͼ20 years ago demonstrated an association between hyperinsulinemia, insulin resistance, and arterial hypertension (1,2). This association was confirmed even after adjustment for body weight and was present in whites but not in blacks (3). Population-based studies have subsequently suggested that insulin resistance and hyperinsulinemia might contribute to progression of cardiovascular disease (4).Elevated plasma aldosterone levels have been implicated in the development and maintenance of high blood pressure in different ethnic groups (5), with a relationship that is stronger in blacks (5) and in obese subjects (6). In the Framingham Offspring Study, normotensive subjects with elevated plasma aldosterone levels, albeit within the normal range, were at high risk of blood pressure elevation and subsequent development of hypertension (7). Moreover, recent evidence indicates that chronic exposure to elevated aldosterone levels might result in substantial damage of the heart and blood vessels. This damage appears to be independent of the blood pres...

show abstract

“…141 Two models of hyperinsulinemia and hypertension in mice reveal a role for insulin-dependent SGK1 activation and ENaC-mediated sodium reabsorption. 142,143 Increased apical targeting of ENaC subunits is seen in sodium avid states such as certain models of nephrotic syndrome or cirrhosis. 144 …”

Section: Kidneymentioning

confidence: 99%

Mechanisms of ENaC Regulation and Clinical Implications

Bhalla¹,

Hallows²

2008

Journal of the American Society of Nephrology

232

182

View full text Add to dashboard Cite

Resistance of mice lacking the serum- and glucocorticoid-inducible kinase SGK1 against salt-sensitive hypertension induced by a high-fat diet

Cited by 66 publications

References 81 publications

The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease

The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease

Insulin Resistance and Hyperinsulinemia Are Related to Plasma Aldosterone Levels in Hypertensive Patients

Mechanisms of ENaC Regulation and Clinical Implications

Contact Info

Product

Resources

About