Resistance of trichostrongyles to benzimidazoles in Italy: a first report in a goat farm with multiple and repeated introductions

Cringoli, Giuseppe; Veneziano, Vincenzo; Rinaldi, Laura; Sauvé, Christine; Rubino, R.; Fedele, V.; Cabaret, Jacques

doi:10.1007/s00436-007-0518-7

Cited by 35 publications

(20 citation statements)

References 17 publications

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“…on sheep farms in Italy. These results support what was reported by Cringoli et al (2007) on the presence of drug-resistant GIT affecting small ruminants in Italy. However, that report demonstrated resistance for benzimidazoles only, and solely for T. colubriformis affecting goats.…”

Section: Resultssupporting

confidence: 83%

“…In the only studies carried out almost 15 years ago, no resistance to any of the three major anthelmintic classes was found (Genchi et al 1993) and, only recently, resistance to benzimidazoles in Trichostrongylus colubriformis has been reported in a goat flock (Cringoli et al 2007). The objective of this study was to determine if multiple drug resistance in GIT species affecting sheep is present in central Italy.…”

Section: Introductionmentioning

confidence: 99%

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First report of multiple drug resistance in trichostrongyles affecting sheep under field conditions in Italy

et al. 2007

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Drug resistance in sheep gastrointestinal trichostrongyles is a cosmopolitan major constraint to small ruminant production. Despite reports that anthelmintic drug resistance has become common, there are limited information on the presence of drug resistance in Italy. The purpose of this study was to determine the effect of four anthelmintics to control infection in sheep in central Italy. Fifty sheep with fecal egg counts (FEC) > or =150 eggs per gram were selected on each of three farms (n = 150 total sheep) which were randomly allocated to one of five groups. Groups were treated with febantel, levamisole, ivermectin, or moxidectin while the fifth group acted as the control group. A FEC reduction test (FECRT) was conducted on each animal and the mean FEC of each treatment group was compared to that of the control group within farm. Resistance was declared when percentage reduction (R) <95% and the lower 95% confidence interval was <90%. Levamisole (mean R = 89%) resistance was found on all farms and ivermectin (mean R = 93%) resistance was found on two of the three farms. Posttreatment larval cultures showed the presence of Teladorsagia (Ostertagia) circumcincta and Trichostrongylus spp. larvae. Febantel (mean R = 96%) and moxidectin (mean R = 100%) remained effective. This study suggests that drug resistance in sheep gastrointestinal trichostrongyles is present in central Italy and a potential problem which would justify a broader nationwide geographical investigation.

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Section: Resultssupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

First report of multiple drug resistance in trichostrongyles affecting sheep under field conditions in Italy

et al. 2007

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“…According to WAAVP recommendations, an evidence of development of resistance in GINs, particularly H. contortus and Trichostrongylus spp., against OXF preparations was found. Previously, benzimidazole resistance against these worms have also been reported in goats (Chartier et al 1995(Chartier et al , 1998Sissay et al 2006;Cringoli et al 2007). …”

Section: Discussionmentioning

confidence: 99%

Prevalence of multiple anthelmintic resistant gastrointestinal nematodes in dairy goats in a desolated tract (Pakistan)

et al. 2008

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This paper presents the first report of anthelmintic resistance (AR) in dairy goats in a desert (Pakistan). Three breeds of dairy goats, i.e. Dera Din Panah, Pak Angora and Beetal, kept at Government Livestock Farm, Rakh Khairewala, district Jhang/Layya, Pakistan, were surveyed for gastrointestinal nematodes (GINs) resistant to commonly used three anthelmintics, i.e. benzimidazole, levamisole and ivermectin. Sixty animals of each breed were selected randomly on the basis of their weight and egg count. Three commonly used anthelmintics, viz., oxfendazole (three different preparations of oxfendazole: fendamex, oxazole, systamex), levamisole and ivermectin, were given at the recommended dose to five groups while one untreated group was kept as control for each breed. Faecal egg counts, faecal egg count reduction test, postmortem worm count and copro-culture were performed to assess the efficacy of selected anthelmintics. The prevalent species of GINs exhibited resistance against all three preparations of oxfendazole. Levamisole in two breeds and ivermectin in all the breeds led to reduction (P< or =0.05) of prevalent species of GINs in both flocks. Haemonchus controtus and Trichostrongylus species exhibited the presence of resistance against oxfendazole preparations which exhibited low efficacy (P> or =0.05). The farm management practices along with the results of the present study revealed the presence of multiple anthelmintic resistant GINs of dairy goats kept in a desolated tract.

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“…However, since parasitic diseases caused by a number of helminth genera such as Teladorsagia, Haemonchus, Trichostrongylus and Dicrocoelium can have a major impact on small ruminant production in the region (Manga-González et al, 2001;Hoste et al, 2005;Rinaldi et al, 2007), effective control strategies can offer considerable economic benefits to small ruminant producers (Jordan and Perez, 1991;Cringoli et al, 2007). Control of these parasitic infections in small ruminants relies almost exclusively on dosing with anthelmintics.…”

Section: Introductionmentioning

confidence: 99%

Effects of strategic anthelmintic treatments on the milk production of dairy sheep naturally infected by gastrointestinal strongyles

Cringoli

Veneziano

Jackson

et al. 2008

Veterinary Parasitology

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The present paper was aimed at assessing the benefit of strategic anthelmintic treatments on milk production in four commercial dairy sheep farms in Southern Italy whose animals were naturally infected by gastrointestinal (GI) strongyles and Dicrocoelium dendriticum. The scheme was based on two treatments timed in relationship to parturition, i.e. the first with moxidectin in the periparturient period and the second with netobimin at the mid/end of lactation. On each farm, two similar groups (20 animals each) were formed, one untreated control group and one group treated according to the above-mentioned scheme. Faecal egg counts (FEC) were performed on each study animal at the start of the trial and then monthly until the end of the study; in addition, milk production was recorded for each animal fortnightly in each farm for the lactation period. The results showed a significant increase in milk yield across all four farms that ranged from 19% to 44% improvement in milk yield. The benefit in milk yield in addition to considerably reduced egg output of the treated animals provide clear evidence that the two main aims of prophylactic parasite control, i.e. to maintain or improve animal performance and to reduce pasture contamination, can be achieved using strategic anthelmintic treatments. #

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Resistance of trichostrongyles to benzimidazoles in Italy: a first report in a goat farm with multiple and repeated introductions

Cited by 35 publications

References 17 publications

First report of multiple drug resistance in trichostrongyles affecting sheep under field conditions in Italy

First report of multiple drug resistance in trichostrongyles affecting sheep under field conditions in Italy

Prevalence of multiple anthelmintic resistant gastrointestinal nematodes in dairy goats in a desolated tract (Pakistan)

Effects of strategic anthelmintic treatments on the milk production of dairy sheep naturally infected by gastrointestinal strongyles

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